Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular docking

AbstractA series of 2-chloro N-substituted amino quinolines (2a –2j) were prepared and characterized by analytical and spectroscopic methods. As quinoline is an important pharmacophoric moiety, the prepared compounds were screened against a non-small cell lung cancer cell line, A549. One of the compounds, 2-chloro-8-methyl-N-(quinolin-5-yl)quinolin-4-amine (2b) is found to be active with inhibition concentration value of (IC50) 29.4  μM. The molecular docking studies with the predominant PI3K/AKT/mTOR pathway proteins also revealed the lesser binding energy with2b. All the compounds are predicted to satisfy the ADME profile and the results let us to consider2b as a lead compound for new generation of A549 cell line inhibitors and for further studies in this way.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research