Chemosensitivity and chemoresistance in endometriosis – differences for ectopic versus eutopic cells

CONCLUSIONSOverall, our results confirm the evidence of large-scale metabolic reprogramming in endometriotic cells, which underlies the observed differences in sensitivity towards toxins. The enhanced efficiency of doxorubicin interfering with redox equilibria and/or DNA repair mechanisms pinpoints key players that can be potentially used for selective targeting of ectopic lesions in endometriosis.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research