Prevention for Zika Virus Infection

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Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research

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Pattern recognition receptors sense pathogen components and initiate host antiviral innate immune responses, including inducing expression of interferons (IFNs). Long non-coding RNAs (lncRNAs) are emerging regulators of multiple biological processes. However, their roles in antiviral responses, especially through regulating the human innate immune system, are largely unexplored. Here, we characterized lncATV, a human-specific lncRNA, and found that it was up-regulated upon type I/III IFN stimulation and viral infection. LncATV was localized in the cytoplasm with relatively high expression in human monocytes, erythroleukemi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Although ZIKV was not confirmed to cause the congenital malformations, this study demonstrated that the clinical and epidemiological findings associated with a STORCH exclusion strengthened the CZS diagnosis. The suspected cases in MT occurred simultaneously with the first CZS cases reported in Brazil, suggesting ZIKV circulation in the study region during the same period.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
CONCLUSIONS: Although ZIKV was not confirmed to cause the congenital malformations, this study demonstrated that the clinical and epidemiological findings associated with a STORCH exclusion strengthened the CZS diagnosis. The suspected cases in MT occurred simultaneously with the first CZS cases reported in Brazil, suggesting ZIKV circulation in the study region during the same period.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Dengue and Zika viruses are closely related mosquito-borne flaviviruses responsible for major public health problems in tropical and sub-tropical countries. The genomes of both, dengue and zika viruses encodes ten genes that are translated into 3 structural proteins (C, prM and E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). The non-structural protein 1 (NS1) is a highly conserved glycoprotein of approximately 48-50 KDa. In infected cells, NS1 is found as a homodimer associated with intracellular membranes and replication complexes, serving as a scaffolding protein in virus replication and morp...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
WEDNESDAY, July 17, 2019 -- Some mosquitoes spread diseases to humans through their bite, passing along harmful pathogens like Zika, dengue fever, West Nile virus and chikungunya. Now humans are turning the tables, infecting these dangerous...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Many flaviviruses including dengue (DENV), and Zika (ZIKV) have attracted significant attention in the past few years. As many flaviviruses are spread by arthropods, most of the world’s population is at risk of encountering a flavivirus, and infection with these viruses has created a significant disease burden worldwide. Vaccination against flaviviruses is thought to be one of the most promising avenues for reducing the disease burden associated with these viruses. The optimism surrounding a vaccine approach is supported by the highly successful vaccines for yellow fever and Japanese Encephalitis. Central to the deve...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The present study shows that the most prominent human arboviruses worldwide (dengue viruses 1, 2, 3, and 4, Chikungunya virus, and Zika virus) can infect wild animals and jump from urban to sylvatic maintenance cycles in South America, as did the yellow fever virus in the past. All these viruses are transmitted by the anthropophilic mosquito Aedes aegypti and cause epidemics throughout Brazil. The yellow fever virus is the oldest example of an urban arbovirus that became sylvatic in South America. Currently, the disease is a zoonosis of non-human primates that moves like a wave through forests of the Brazilian countryside,...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In conclusion, SIAT is still evolving, as is the Medical Genetics Service that hosts it. Through its 27 years of existence more than 300 undergraduate and graduate students have rotated at SIAT. Presently, SIAT is expanding the research to experimental teratogenesis and to investigation of molecular mechanisms of teratogens.
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Abstract Japanese encephalitis virus (JEV) and West Nile virus (WNV) are two major mosquito borne flaviviruses belonging to same serocomplex. JEV is transmitted by Culex mosquitoes and the reservoir host for the virus is pigs and/or water birds. WNV is also transmitted by Culex mosquitoes and reservoir host in this case is birds. It can also be transmitted through contact with other infected animals, their blood, or other tissues. The envelope protein of these viruses is the major source of epitopes and provides protective immunity. Bioinformatics tools were used to identify conserved epitopes in the envelope prot...
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
Y. Romer et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
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