Association between polymorphisms of a folate - homocysteine - methionine - SAM metabolising enzyme gene and multiple sclerosis in a Polish population.

CONCLUSIONS: It was found that, regardless of the presence of a specific allele, the gender of MS patients affects the age differences at the time of the clinical onset of the disease: in rs1801133 for the C allele and T, the average age was 35 for female and 29 for men (p = 0.0004; p = 0.034 respectively). Similarly for the second polymorphism rs1801131 for the A allele and C the average age was 35 for female and 29 for men (p = 0.001; p = 0.01 respectively). No significant allelic / genotypic frequency differences have been observed between the studied groups (c.677C > T, CT/TT p = 0.719, p = 0.262; c.1298A > C, AC/CC of p = 0.686; p = 0.66). We found no association between polymorphisms of a folate - homocysteine - methionine - SAM metabolizing gene enzyme and multiple sclerosis in polish population. PMID: 31145465 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Tags: Neurol Neurochir Pol Source Type: research