The dependence of FMD% on baseline diameter: a problem solved by allometric scaling

DeVan et al. recently found that both percentage flow mediated dilation (FMD%) and baseline artery diameter differed between their study samples. In this correspondence, I question to what extent the dependence of FMD% on baseline diameter confounded the estimates of endothelial dysfunction. Rather than covariate-adjusting FMD% itself for baseline diameter, I discuss the application of recent advances in allometric scaling in this field of research,

Source: Clinical Science - January 28, 2013 Category: Biomedical Science Authors: G Atkinson Source Type: research