In the Loop: Special delivery -- how one EMT helped transport his uncle's new heart

Teddy Ross, an emergency medical technician, had just driven a heart by ambulance to Mayo Clinic when he realized that the heart was for his uncle, who was there awaiting a transplant. What started out as just another "ordinary day" for Teddy Ross quickly turned into a day he and his family will never forget. [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

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Being born and giving birth is full of pain, blood, and trauma. Many science fiction works, such as Brave New World, Matrix, The Island, or I am Mother imagine being brought to the world without actually being born in a mother’s womb. How far-fetched are these scenarios? Could the appearance of the artificial womb replace human mothers and natural birth in the future? How will we come into this world in 2050? Will we be born? The trauma of being born and giving birth The experience of being born and leaving the nurturing womb of our mother after more or less nine months is painful, bloody, and traumatic. Abrupt...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Medical Science Fiction artificial artificial womb baby birth designer baby Health Healthcare Innovation mother sci-fi scifi society technology uterus Source Type: blogs
AbstractOur aim was to describe the clinical profile of patients presenting sustained ventricular arrhythmias after sacubitril/valsartan (SV) initiation. All cases of sustained ventricular arrhythmias in patients receiving SV were consecutively recorded in two centers. Nineteen patients had sustained ventricular arrhythmias after SV. All were men and were previously receiving angiotensin-converting enzyme inhibitors, or angiotensin II receptor blockers before SV initiation. Fifteen patients (78.9%) had electrical stability in the previous 6  months. Nine patients (47.4%) initiated SV at the lowest available dose (24/2...
Source: Heart and Vessels - Category: Cardiology Source Type: research
The European Pediatric PVD Network (EPPVDN) is a registered, non-profit organization that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of pediatric pulmonary hypertensive vascular disease, including pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD), PH associated with congenital heart disease (CHD), persistent PH of the newborn (PPHN), and related cardiac dysfunction. The executive writing group (EWG) members conducted searches of the PubMed/MEDLINE bibliographic database (1990-2018), held face-to-face and web-based meetings.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
AbstractPurpose of ReviewCardiovascular disease is the leading cause of mortality worldwide. Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have great potential to treat heart disease, owing to their capacity of engraftment and remuscularization in the host heart after transplantation. In the current review, we provide an overview of PSC-CMs for clinical transplantation.Recent FindingsStudies have shown that PSC-CMs can survive, engraft, and form gap junctions after transplantation, with functional benefit. Engrafted PSC-CMs matured gradually in host hearts. Only in a large animal model, transient ventricular arrhy...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
We describe our experience of bivalirudin use, a newer direct thrombin inhibitor, in an infant who was supported with Berlin Heart EXCOR VAD (Berlin VAD) as bridge to transplant for 122 days without complications and without need for pump exchange. An 11-month-old girl with dilated cardiomyopathy with acute heart failure was awaiting cardiac transplant. Lack of improvement despite maximizing medical therapy and anticipating a prolonged waitlist time, she was supported with Berlin LVAD as a bridge to transplant. Anticoagulation with bivalirudin was started and titrated with a goal partial thromboplastin time of 60-90...
Source: Perfusion - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Perfusion Source Type: research
Publication date: August 2019Source: American Heart Journal, Volume 214Author(s): Tracey Ying, Jagbir Gill, Angela Webster, S. Joseph Kim, Rachael Morton, Scott W. Klarenbach, Patrick Kelly, Timothy Ramsay, Gregory A. Knoll, Helen Pilmore, Gillian Hughes, Charles A. Herzog, Steven Chadban, John S. GillTransplantation is the preferred treatment for patients with kidney failure, but the need exceeds the supply of transplantable kidneys, and patients routinely wait>5 years on dialysis for a transplant. Coronary artery disease (CAD) is common in kidney failure and can exclude patients from transplantation or result in dea...
Source: American Heart Journal - Category: Cardiology Source Type: research
Condition:   Hematologic Malignancy Intervention:   Diagnostic Test: Age 60+ with planned HCT for Hematologic Malignancy Sponsors:   Center for International Blood and Marrow Transplant Research;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   National Cancer Institute (NCI);   Blood and Marrow Transplant Clinical Trials Network;   National Marrow Donor Progra m Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: July 2019Source: The Annals of Thoracic Surgery, Volume 108, Issue 1Author(s): Ji-ming Sha, Yi Cao, Sheng-song XuAnomalous origin of the pulmonary artery from the ascending aorta can lead to congestive heart failure in infancy, and with advancing age many patients will experience severe pulmonary hypertension. Surgical intervention has high mortality and morbidity risks if this happens. Strategies to manage these patients seem only limited to heart–lung transplantation or lung transplantation. Here, we successfully performed surgical intervention in an adult patient who had anomalous origin of the r...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractPurpose of ReviewHeart transplantation is the gold standard therapy for end-stage heart failure; however, the donor pool is limited, making this a scarce resource that must be allocated to the sickest patients in an efficient, fair, and equitable manner. The allocation policies have been constantly revised over the years to refine the process. We will explore the new heart allocation system, OPTN-Policy 6, as well as, review why these changes were necessary.Recent FindingsOver the past decade, the number of active heart transplant candidates nearly doubled, with a dramatic increase in the number of status 1A and 1B...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by fibro-thrombotic obstruction of large pulmonary arteries combined with small-vessel arteriopathy. This subsequently leads to the development of pulmonary hypertension, right-heart failure and death.1 The etiology of CTEPH is not always clear. While up to 75% of patients with CTEPH have been previously diagnosed with an acute pulmonary embolism, only 4% of patients diagnosed with acute PE develop CTEPH as a complication.2
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
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