Many Heart Failure Patients Might Safely Reduce Use of Diuretics

Title: Many Heart Failure Patients Might Safely Reduce Use of DiureticsCategory: Health NewsCreated: 5/31/2019 12:00:00 AMLast Editorial Review: 5/31/2019 12:00:00 AM
Source: MedicineNet Heart General - Category: Cardiology Source Type: news

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Publication date: Available online 16 June 2019Source: Pharmacological ResearchAuthor(s): Vasundhara Kain, Jeevan Kumar Jadapalli, Bochra Tourki, Ganesh V. HaladeAbstractLifestyle or age-related risk factors over-activate the inflammation that triggers acute heart failure (HF)-related mortality following myocardial infarction (MI). Post-MI activated leukocytes express formyl peptide receptor 2 (FPR2) that is essential for inflammation-resolution and in cardiac healing. However, the role of FPR2 in acute HF is incomplete and remain of interest. Here, we aimed to determine whether pharmacological inhibition of FPR2 perturb l...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
National reporting and incentive schemes, such as the Quality and Outcomes Framework, have not prevented suboptimal management of heart failure in the UK, research published in PLoS Medicine has concluded.
Source: Clinical Pharmacist - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Typhaneoside regulates IL-6 and TNF-α as well as MMP-2 and MMP-9 in rats with heart failure after myocardial infarction. Typhaneoside can improve cardiac morphological structure and myocardial remodeling and enhance heart function. It may mediate autophagy inhibition in the cardiomyocyte anoxia/reoxygenation (A/R) pathway through the PI3K/Akt/mTOR autophagy transduction pathway. PMID: 31201434 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Publication date: Available online 15 June 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Andrew F. Stephens, Andrew Busch, Robert F. Salamonsen, Shaun D. Gregory, Geoffrey D. TansleyAbstractVentricular assist devices are used to support patients with end-stage heart failure. Many patients on long-term VAD support are treated out-of-hospital where monitoring technology for patients is severely limited; leading to sub-optimal patient management. This paper describes a novel fibre Bragg grating (FBG) pressure sensor which was developed for improved monitoring of patients with ventricular assist devices. The FBG sens...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
This study aims to assess prognostic impact of Framingham criteria for heart failure (FC ‐HF) in patients with stable heart failure (HF) with preserved ejection fraction (HFpEF).Methods and resultsIn the prospective Karolinska ‐Rennes (KaRen) study, we assessed stable HFpEF patients after an acute HF episode. We evaluated associations between the four descriptive models of HFpEF and the composite endpoint of all‐cause mortality and HF hospitalization. The descriptive models were FC‐HF alone, FC‐HF + natriuretic peptides (NPs) according to the PARAGON trial, FC‐HF + NPs + echocardio...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Cell Death &Differentiation, Published online: 17 June 2019; doi:10.1038/s41418-019-0374-xDeletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure
Source: Cell Death and Differentiation - Category: Cytology Authors: Source Type: research
AbstractThe identification of specific patients with decompensated heart failure (DHF) who may benefit from ultrafiltration (UF) is important in clinical practice. We undertook a meta-analysis to compare the effects of ultrafiltration and diuretics on major clinical outcomes. The outcomes included weight change, length of hospital stay, rehospitalization for HF, mortality, change in serum creatinine, dialysis dependence, and adverse outcomes. We identified 14 trials including 975 patients with HF, met the eligibility criteria. There was a reduction in heart failure-related rehospitalization in ultrafiltration group when co...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
AbstractHeart failure represents the end result of different pathophysiologic processes, which culminate in functional impairment. Regardless of its aetiology, the presentation of heart failure usually involves symptoms of pump failure and congestion, which forms the basis for clinical diagnosis. Pathophysiologic descriptions of heart failure with reduced ejection fraction (HFrEF) are being established. Most commonly, HFrEF is centred on a reactive model where a significant initial insult leads to reduced cardiac output, further triggering a cascade of maladaptive processes. Predisposing factors include myocardial injury o...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
ConclusionsSNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF. The data suggests an additive predictive value of these SNPs for a HF prognosis. In particular for obese patients, SNPs rs10423928, rs1800437, rs737337 and rs9351814 were related with a bad prognosis. Combined scores weighting the risk of each genomic variant could effect interesting new tools to stratify the prognostic risk of HF patients.
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductas...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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