Classic bladder exstrophy and adenocarcinoma of the bladder: methylome analysis provide no evidence for underlying disease-mechanisms of this association

The bladder exstrophy-epispadias complex represents the severe end of human congenital anomalies of the kidney and urinary tract (CAKUT) that also involves defect in abdominal wall, pelvis, genitalia, occasionally the spine and anus [1, 2]. The severity-spectrum of the BEEC comprises the mild form (epispadias/E), intermediate form (classic bladder exstrophy/CBE), and the severe form (exstrophy of the cloaca/CE). Long-term complications of CBE are malignancies of the bladder with 95% of these being adenocarcinomas [3].

Source: Cancer Genetics and Cytogenetics - May 30, 2019 Category: Genetics & Stem Cells Authors: Amit Sharma, Holger Fr öhlich, Rong Zhang, Anne-Karoline Ebert, Wolfgang Rösch, Henning Reis, Glen Kristiansen, Jörg Ellinger, Heiko Reutter Tags: Short Communication Source Type: research