Deregulated miRNAs in osteoporosis: effects in bone metastasis.

Deregulated miRNAs in osteoporosis: effects in bone metastasis. Cell Mol Life Sci. 2019 May 30;: Authors: Bellavia D, Salamanna F, Raimondi L, De Luca A, Carina V, Costa V, Alessandro R, Fini M, Giavaresi G Abstract Starting from their role exerted on osteoblast and osteoclast differentiation and activity pathways, microRNAs (miRNAs) have been recently identified as regulators of different processes in bone homeostasis. For this purpose, in a recent review, we highlighted, as deregulated miRNAs could be involved in different bone diseases such as osteoporosis. In addition, recent studies supported the concept that osteoporosis-induced bone alterations might offer a receptive site for cancer cells to form bone metastases, However, to date, no data on specific-shared miRNAs between osteoporosis and bone metastases have been considered and described to clarify the evidence of this link. The main goal of this review is to underline as deregulated miRNAs in osteoporosis may have specific roles in the development of bone metastases. The review showed that several circulating osteoporotic miRNAs could facilitate tumor progression and bone-metastasis formation in several tumor types, i.e., breast cancer, prostate cancer, non-small-cell lung cancer, esophageal squamous cell carcinoma, and multiple myeloma. In detail, serum up-regulation of pro-osteoporotic miRNAs, as well as serum down-regulation of anti-osteoporotic miRNAs are common features of all these tumors...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research

Related Links:

Those suffering from cancer, heart conditions, strokes, diabetes and lung disease are among the worst affected by delays to their diagnosis and care, a survey of senior doctors reveals.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
How does sustained virologic response from direct-acting antiviral and interferon-based treatments impact the risk of developing hepatocellular carcinoma?Journal of Viral Hepatitis
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Gastroenterology Journal Article Source Type: news
The objective of this study was to report the incidence of alopecia arising in patients treated with vismodegib, assessing its characteristics, grade of severity, and time of onset.Skin Appendage Disord
Source: Skin Appendage Disorders - Category: Dermatology Source Type: research
CONCLUSIONS: Surprisingly, the DCR registered fewer patients in 2013-2014 than the DLCR, even though they employ the same primary data source. The agreement between the DCR and the DLCR was 87%; this may be increased to 95% if patients who seemed to meet the inclusion criteria of the other register were also included. The discrepancies found were mainly due to different definitions of dates of diagnosis, registrations probably missed by the algorithms and possible registration errors. Discrepancies resulted in a significant difference in MRR, but not in 1y-RS. FUNDING: none. TRIAL REGISTRATION: not relevant. PM...
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
CONCLUSIONS: Most women did not experience any improvement in their symptoms over time, and no association was found between lack of symptom improvement and believing that the HPV vaccine was causing the symptoms. FUNDING: funded by the Danish Cancer Society. TRIAL REGISTRATION: not relevant. PMID: 32741432 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
Date: Friday, 09 25, 2020; Speaker: Dr. Dauod Meerzaman; Building: Building 10 (Clinical Center); This class is presented as a webinar only; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Wednesday, 05 12, 2021; Speaker: Christine Ambrosone, Ph.D., University of Buffalo; 6100 Executive Boulevard; 3rd Floor Conference Room
Source: NIH Calendar of Events - Category: American Health Source Type: events
Liver Cancer 2020;9:477 –478
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
Authors: Bera A, Russ E, Srinivasan M, Eidelman O, Eklund M, Hueman M, Pollard HB, Hu H, Shriver CD, Srivastava M PMID: 32744311 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
(Wiley) Vaccination against the human papilloma virus (HPV) reduces the risk of a condition that often leads to cervical cancer, according to an analysis of Danish health registry data.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
More News: Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Cytology | Esophagus Cancer | Lung Cancer | Myeloma | Non-Small Cell Lung Cancer | Orthopaedics | Osteoporosis | Prostate Cancer | Skin Cancer | Squamous Cell Carcinoma | Study