Functional relaxant effect of 6,7-dipropoxy-2 H -chromen-2-one is mainly by calcium channel blockade in ex vivo assay of tracheal rings

In conclusion,6,7-DPC showed a relaxant effect due to combined mechanism of action on rat tracheal rings, through non-competitive muscarinic receptor functional antagonism and preventing the calcium influx. This provides pharmacological basis for the use of6,7-DPC in airways disorders, such as asthma or chronic obstructive pulmonary disease (COPD).

http://link.springer.com/10.1007/s00044-019-02364-y

Source: Medicinal Chemistry Research - May 30, 2019 Category: Chemistry Source Type: research