Phase Separation as a Melting Pot for DNA Repeats

Publication date: Available online 31 May 2019Source: Trends in GeneticsAuthor(s): Amanda C. Hall, Lauren A. Ostrowski, Karim MekhailGenome expression and stability are dependent on biological processes that control repetitive DNA sequences and nuclear compartmentalization. The phase separation of macromolecules has recently emerged as a major player in the control of biological pathways. Here, we summarize recent studies that collectively reveal intersections between phase separation, repetitive DNA elements, and nuclear compartments. These intersections modulate fundamental processes, including gene expression, DNA repair, and cellular lifespan, in the context of health and diseases such as cancer and neurodegeneration.
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research