Chiaravalloti receives grant to study cognition and hemodynamics after spinal cord injury

(Kessler Foundation) This grant will enable Dr. Chiaravalloti's group to extend their research into the relationship between cardiovascular and cerebrovascular dysfunction and poorer cognitive performance in persons with spinal cord injury. 'Our research shows that deficits in learning and memory are prevalent in this population,' noted Dr. Chiaravalloti. 'Understanding how cardiovascular, cerebrovascular and cognitive function change over time in this population will help us develop ways to prevent or minimize the impact of these functional deficits.'
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Abstract In this chapter, we first describe two interchangeable protocols optimized in our lab for deriving definitive neuronal progenitor cells from human pluripotent stem cells (hPSCs). The resultant NPCs can then be propagated and differentiated to produce differing proportions of neurons, oligodendrocytes, and astrocytes as required for in vitro cell culture studies or in vivo transplantation. Following these protocols, we explain the method for transplanting these cells into the rat model of spinal cord injury (SCI). PMID: 30656619 [PubMed - indexed for MEDLINE]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductas...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: Normocapnic hyperpnoea training may reduce the incidence of respiratory symptoms, improve pulmonary function and quality of life, and reduce depression in patients with chronic spinal cord injury, regardless of their neurological level of injury, even at more than 24 months after injury. PMID: 31198974 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
Conclusion: Based on our results healthcare providers should work with individuals with cervical SCI to develop long term PROM plans to optimize functional abilities. PMID: 31192777 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Conditions:   Spinal Cord Injuries;   Neurogenic Bowel;   Bladder Dysfunction Interventions:   Dietary Supplement: Human Milk Oligosaccharides (HMO);   Other: Placebo Sponsors:   Lawson Health Research Institute;   The W. Garfield Weston Foundation;   St. Joseph's Health Care London;   Parkwood Hospital, London, Ontario Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 13 June 2019Source: Stem Cell ReportsAuthor(s): Paul Lu, Walace Gomes-Leal, Selin Anil, Gabriel Dobkins, J. Russell Huie, Adam R. Ferguson, Lori Graham, Mark TuszynskiSummaryNeural progenitor cells (NPCs) transplanted into sites of spinal cord injury (SCI) extend large numbers of axons into the caudal host spinal cord. We determined the precise locations of neurons in the graft that extend axons into the caudal host spinal cord using AAV9-Cre-initiated retrograde tracing into floxed-TdTomato-expressing NPC grafts. 7,640 ± 630 grafted neurons extended axons to a single caudal host s...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Spinal cord injury (SCI) can lead to severe and permanent functional deficits. In humans, peri-auricular muscles (PAMs) do not serve any physiological function, though their innervation is preserved in even hi...
Source: Journal of NeuroEngineering and Rehabilitation - Category: Rehabilitation Authors: Tags: Research Source Type: research
CONCLUSIONS: Appropriate stratification factors are fundamental to accurately identify treatment effects. Inclusion of AOSC type improves stratification, and use of the 6 stratification groups could minimize confounding effects of variable neurological recovery so that effective treatments can be identified. PMID: 31200369 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery.Spine - Category: Neurosurgery Authors: Tags: J Neurosurg Spine Source Type: research
In this study, we explored the proposed PNM‐CAN mechanism in SCI + NP and AB cohorts following centrally‐directed neuromodulation to assess if the PNM and CAN are capable of being differentially modulated.Materials and MethodsCentral neuromodulation was administered via breathing ‐controlled electrical stimulation (BreEStim), previously evidenced to operate at the PNM. To quantify CAN activity, conventional heart rate variability (HRV) recordings were used to gather time and frequency domain parameters of autonomic modulation. SCI + NP (n = 10) and AB (n = 13) cohorts received null and act...
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Clinical Research Source Type: research
Polymethylmethacrylate (PMMA) is the most commonly used filling material when performing percutaneous kyphoplasty (PKP) for the treatment of osteoporotic vertebral compression fractures. However, there are some inherent and unavoidable drawbacks with the clinical use of PMMA. PMMA bone cement tends to leak during injection, which can lead to injury of the spinal nerves and spinal cord. Moreover, the mechanical strength of PMMA-augmented vertebral bodies is extraordinary and this high level of mechanical strength might predispose to adjacent vertebral fractures.
Source: The Spine Journal - Category: Orthopaedics Authors: Tags: Basic Science Source Type: research
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