Personalized and precision medicine as informants for treatment management of bipolar disorder

DSM-5 diagnostic categories, defined by a set of psychopathological symptoms are heterogeneous conditions that may include different biological entities, with distinct etiopathogenesis, different courses and requiring different treatment management. For bipolar disorder the major evidences for this lack of validity are the long paths before a proper diagnosis, the inconsistence of treatment guidelines, the long phases of pharmacological adjustment and the low average of long-term treatment response rates. Personalized medicine for mental disorders aims to couple established clinical–pathological indexes with new molecular profiling to create diagnostic, prognostic and therapeutic strategies precisely tailored to each patient. Regarding bipolar disorder, the clinical history and presentation are still the most reliable markers in stratifying patients and guiding therapeutic management, despite the research goes to great lengths to develop new neuropsychological or biological markers that can reliably predict individual therapy effectiveness. We provide an overview of the advancements in personalized medicine in bipolar disorder, with particular attention to how psychopathology, age at onset, comorbidity, course and staging, genetic and epigenetic, imaging and biomarkers can influence treatment management and provide an integration to the conventional treatment guidelines. This approach may offer a new and rational path for the development of treatments for targeted subgr...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Review Source Type: research

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Publication date: Available online 26 February 2020Source: American Journal of OtolaryngologyAuthor(s): Michelle White, Elie Rebeiz
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Conclusions: In this sample, TT levels were related to valproate use in patients with BD. More studies regarding the role of testosterone in affective symptoms should be conducted to clarify the relation between testosterone, affective disorders, and medication.KeypointsWe observed that testosterone levels were significant higher in bipolar women compared to women with MDD.The use of valproate could be associated with the testosterone levels in female patients with BD.Evaluation of women suffering BD should include a testosterone levels determination, particularly when they are taking valproate. PMID: 32096661 [PubMed ...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
Objectives: To compare demographic, clinical, and familial characteristics across bipolar disorder (BD) subtypes in adolescents. Methods: ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
ConclusionsFindings suggest lower self ‐esteem and specific dysfunctional beliefs around dependency may precede symptoms of depression. Further research is required to further explore these associations.Practitioner points Elevated dysfunctional beliefs around dependency on others and lower levels of self ‐esteem may precede symptoms of depression in BD. Therapeutic interventions and relapse prevention targeting these psychological factors may help reduce the risk of depression relapse.
Source: Psychology and Psychotherapy: Theory, Research and Practice - Category: Psychiatry & Psychology Authors: Tags: Original Article Source Type: research
Conclusions: PLWH with mood disorders were at increased risk of incident NCDs and multimorbidity, particularly metabolic syndrome. Focused prevention and treatment of NCDs may reduce the burden of multimorbidity in this high-risk group.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Clinical Science Source Type: research
Authors: Oh S Abstract BACKGROUND AND OBJECTIVES: It is difficult to estimate the depth of the focal source by activation mapping. The present study was performed to demonstrate the usefulness of a simple maneuver in estimating the depth of the focal activation source (S). METHODS: A total of 44 sites (15 shallow, depth5.5 mm) were analyzed in 3 canine left ventricles under general anesthesia. A custom-made bipolar needle electrode was used to simulate a focal activation source. A mapping catheter with an electrode tip size of 2 mm, band electrode size of 1 mm, and inter-electrode spacing of 2-10-2 mm was place...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Having a baby is a wonderfully happy time, right? For many women, it certainly is, but estimates show that 1 in 5 women who give birth will suffer from some type of perinatal mental illness, such as depression, anxiety, OCD or psychosis. Chances are, this includes someone you know. In today’s podcast, Dr. Katayune Kaeni, a psychologist who specializes in perinatal mental health and a sufferer herself, discusses these often confusing and debilitating disorders, particularly postpartum psychosis, a more rare and severe form of perinatal mental illness. Who is at risk? What does perinatal psychosis look like? And what ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Children and Teens Disorders General Interview Parenting Podcast Pregnancy The Psych Central Show Women's Issues Source Type: blogs
Publication date: Available online 27 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Andre Delgado, Jorge Velosa, Junyu Zhang, Serdar Dursun, Flavio Kapczinski, Taiane de Azevedo Cardoso
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Conclusion: Despite using a large cohort and highly controlled laboratory conditions, we found no differences in melatonin suppression between euthymic patients with bipolar I disorder and healthy controls. These findings do not support the notion that supersensitivity is a valid endophenotype in bipolar I disorder. PMID: 32096617 [PubMed - in process]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research
CONCLUSIONS.: This study provided an atlas of genetic correlations between psychiatric disorders and plasma proteome, providing novel clues for pathogenetic and biomarkers, therapeutic studies of psychiatric disorders. PMID: 32093803 [PubMed - in process]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
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