Preliminary Effectiveness of Auricular Point Acupressure on Chemotherapy-Induced Neuropathy: Part 1 Self-Reported Outcomes

To reduce chemotherapy-induced neuropathy (CIN) —a significant challenge among cancer patients following chemotherapy—we explored the effects of auricular point acupressure (APA), which involves needleless, acupuncture-like stimulation on specific ear points.
Source: Pain Management Nursing - Category: Nursing Authors: Tags: Original Article Source Type: research

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e Reviews are a fundamental space for summarizing and spreading knowledge on a particular topic. Methodologic skills may improve the clarity and the meaning of data presentation. A recent editorial choice provided an advanced update on a topic such as cancer pain, providing meaningful and appropriate information on hot topics of cancer pain management. Recent reviews have reported strange and misleading data, suggesting to some adjuvant drugs or opioids for mild-moderate pain instead of opioids on the basis of an incomprehensible analysis performed without any clinical sense. This is a serious problem because such info...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Editorial Source Type: research
This study investigated the role of DLC2 and its downstream cascade of RhoA/ROCK in formalin-induced inflammatory pain using DLC2-knockout (DLC2-/-) mice and compared them with DLC2 wild-type (DLC2+/+) mice. Mechanical allodynia and thermal hyperalgesia were evaluated using von Frey filament aesthesiometer and Hargreaves test, respectively. The spinal cord dorsal horn (L3-L5) was selected for molecular and cellular identification by Western blot and immunofluorescence. DLC2-/- mice showed increased mechanical allodynia and thermal hyperalgesia. Expression of ROCK1, ROCK2 and IL-1β was significantly higher in DLC2-/- m...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting side effect of treatment with neurotoxic cancer treatments, including platinum compounds, taxanes, vinca alkaloids, thalidomide, and bortezomib.79 Symptoms of CIPN include paraesthesia, numbness and weakness in the extremities, typically resulting from damage to large sensory as well as motor nerve fibers. However, small fiber components of the peripheral nervous system can also be affected, resulting in autonomic dysfunction and pain.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Review Article Source Type: research
ConclusionsAdult brain tumour survivors were found to experience poorer SCF than healthy controls after accounting for anxiety. SCF was related to multiple factors after brain tumour; however, an independent association with anxiety was identified.Implications for Cancer SurvivorsThese findings highlight the potential value of psychological interventions targeting anxiety and cognitive effects to improve quality of survivorship after brain tumour.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
Family caregivers play a vital role in managing the pain of hospice patients with cancer; however, caregivers ’ knowledge of pain management principles and experiences as pain managers vary widely. Differences in cultural values and access to resources suggest that rural and urban hospice family caregivers may differ with regard to their pain knowledge and experience, but this has not been empirically inv estigated.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Conclusion.These data support the use of cordotomy for pain refractory to optimal palliative care. The findings of this study justify a large‐scale randomized controlled trial of percutaneous cordotomy.Implications for Practice.This prospective clinical trial was designed to determine the improvement in pain intensity in patients randomized to either undergo cordotomy or comprehensive palliative care for medically refractory cancer pain. This study shows that cordotomy is effective in reducing pain for medically refractory cancer pain, and these results can be used to design a large‐scale comparative randomized control...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Symptom Management and Supportive Care Source Type: research
We describe herein a patient with metastatic melanoma who developed epididymo‐orchitis followed by encephalitis while receiving pembrolizumab. The patient developed testicular pain and fever after his third dose of pembrolizumab; ultrasound evaluation demonstrated bilateral epididymo‐orchitis. He then developed headaches, fever, and altered mental status over the next week and was admitted to the hospital. Lumbar puncture revealed inflammatory changes consistent with meningoencephalitis; he did not improve with broad‐spectrum antibiotics, and an extensive workup for infectious etiologies, including cerebrospinal flui...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Melanoma and Cutaneous Malignancies Immune ‐ Related Adverse Events Source Type: research
Conclusions: Hence, we conclude that culturally familiar instrumental classical music demonstrates a significant effect in alleviating pain, anxiety, and low mood as an adjunct to on-going therapies in cancer patients.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Conclusions: The improvement in QOL parameters suggests that the regimen of 52.5 Gy in 15 fractions is suitable for palliative intent radiotherapy in late-stage oral cavity cancer for effective palliation for short periods.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
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