Adipose Progenitor Cells Contribute to Lipid Spillover during Obesity

Publication date: Available online 29 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Nabil Rabhi, Stephen R. FarmerA recent study (Girousse et al. Cell Rep. 2019;27:323–333) shows that CXCR4+ adipose progenitors (APCs) contribute to lipid spillover during high-fat feeding through their release from subcutaneous fat depots (ScATs) and migration to skeletal muscle where they differentiate into adipocytes. Pharmacological antagonism of CXCR4, which prevents the CXCL12-dependent retention of APCs in ScAT, mimics the effects of overfeeding.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research