Desferrioxamine and dextromethorphan combination exhibited synergistic effect and reversed the catalepsy behaviour in 6 ‐hydroxydopamine hydroydopamine administered rats through regulating brain glutamate levels

ConclusionsThe reversal of catalepsy behaviour represents the protective effect of above combination on dopamine neurons in striatum from 6 ‐OHDA toxicity. The mechanism of DFO and DXM combination might be attributed through attenuation of glutamate‐induced excitotoxicity in neurons through ameliorating the reactive oxygen species and pro‐inflammatory cytokines release. Treatment with DFO and DXM combination could control the mult iple events in the pathogenesis of PD.

Source: Journal of Pharmacy and Pharmacology - May 28, 2019 Category: Drugs & Pharmacology Authors: Navaf Mannan Thodukayil, Justin Antony, Peet Thomas, Victoria Jeyarani, Tenzin Choephel, Chennu Manisha, Asha Jose, Santilna Karolina Sahadevan, Elango Kannan Tags: Research Paper Source Type: research