Neuropeptide Y predicts cardiovascular events in chronic kidney disease patients: a cohort study

Background: Neuropeptide Y (NPY) is a multifaceted sympathetic neurotransmitter regulating reflex cardiovascular control, myocardial cell growth, inflammation and innate immunity. Circulating NPY levels predict cardiovascular mortality in patients with end stage kidney disease on dialysis but this relationship has never been tested in predialysis chronic kidney disease (CKD) patients. Methods: We investigated the relationship between circulating NPY and the risk for cardiovascular events (Fine & Gray competing risks model) in a cohort of 753 stages 2–5 CKD patients over a median follow-up of 36 months. Results: Independently of other risk factors, plasma NPY was directly related with the glomerular filtration rate (β = −0.19, P 
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research