New HRS Consensus on Arrhythmogenic Cardiomyopathy New HRS Consensus on Arrhythmogenic Cardiomyopathy
A new consensus statement provides guidance on evaluation and management of arrhythmogenic cardiomyopathy, including clinically relevant information on genetics and disease mechanisms.Medscape Medical News
India leads the world with the largest number of diabetes patients, thereby known as “Diabetic Capital of the World”, having more than 62 million diabetic individuals diagnosed with the disease [1,2]. The rapid epidemiological transition associated with unhealthy dietary patterns, physical inactivity are considered as main drivers to give a higher prevalence of diabetes in the u rban population . Type 2 diabetes mellitus (T2DM) is the commonest form of diabetes with a prevalence of 2.4% in the rural population and 11.6% in the urban population .
ConclusionsThe change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.
ConclusionExogenous treatment of PGE2 and the EP4 receptor agonist blocked the pro-inflammatory actions of LPS. Mechanistically, this was mediated via reduced Akt phosphorylation and inhibition of NF-κB.
Conditions: Dilated Cardiomyopathy; Left Ventricular Systolic Dysfunction; Fibrosis Myocardial Interventions: Device: ICD; Device: ILR Sponsor: Flinders University Not yet recruiting
Authors: Lau DH, Kalman JM, Sanders P PMID: 31216054 [PubMed - as supplied by publisher]
AbstractWe recently experienced a case of cardiogenic shock due to influenza-related Takotsubo cardiomyopathy with atrial tachycardia and respiratory distress syndrome. Temporary mechanical circulatory support by IMPELLA 2.5 improved end-organ failure and resulted in cardiac recovery with sinus rhythm conversion.
This article is protected by copyright. All rights reserved
CONCLUSION: A strong link between bone marrow metabolism and impaired myocardial function and perfusion was observed in women, but not in men. Our data suggest that novel biomarkers of inflammation might help to identify women at risk for ischemic cardiomyopathy and to tailor disease management to the female cardiovascular phenotype. PMID: 31226718 [PubMed - as supplied by publisher]
Neuropediatrics DOI: 10.1055/s-0039-1692129Congenital disorders of autophagy are multisystem disorders with significant neurological involvement. Ectopic p-granules protein 5 (EPG5)-associated Vici syndrome is a prototypical congenital disorder of autophagy and presents with the cardinal features of agenesis of the corpus callosum, cataracts, cardiomyopathy, immunodeficiency, and oculocutaneous hypopigmentation. The majority of EPG5 variants leading to Vici syndrome are null alleles with only a few missense variants published to date. Here we report a 3.5-year-old male with compound heterozygous EPG5 variants [NM_020964.2:...
We describe our experience of bivalirudin use, a newer direct thrombin inhibitor, in an infant who was supported with Berlin Heart EXCOR VAD (Berlin VAD) as bridge to transplant for 122 days without complications and without need for pump exchange. An 11-month-old girl with dilated cardiomyopathy with acute heart failure was awaiting cardiac transplant. Lack of improvement despite maximizing medical therapy and anticipating a prolonged waitlist time, she was supported with Berlin LVAD as a bridge to transplant. Anticoagulation with bivalirudin was started and titrated with a goal partial thromboplastin time of 60-90...