Sirolimus Linked to Lower Malignancy After Heart Transplant Sirolimus Linked to Lower Malignancy After Heart Transplant

A single-center cohort analysis demonstrates that converting heart transplant patients from standard immunosuppression to regimens that use sirolimus is associated with improved 10-year survival.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news

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Publication date: Available online 19 October 2019Source: The Annals of Thoracic SurgeryAuthor(s): Leona T. Yarboro
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsRisk stratification for cardiac amyloidosis with the newly developed “HeiRisk” score may be superior to other staging systems for patients with advanced heart failure due to amyloid cardiomyopathy.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
Publication date: October 2019Source: Clinical Lymphoma Myeloma and Leukemia, Volume 19, Issue 10, SupplementAuthor(s): Inhwan Hwang, Dok Hyun Yoon, Cheolwon Suh, Jea-Joong kim, Chan-Jeoung Park, Jae Won Lee, Tae-Jin Yun, Sung Ho Jung, Min-Seok Kim, Heejung Chae
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 16 October 2019Source: Pharmacological ResearchAuthor(s): Sivakkanan Loganathan, Yuxing Guo, Weipeng Jiang, Tamás Radovits, Mihály Ruppert, Alex Ali Sayour, Maik Brune, Paige Brlecic, Phillipp Gude, Adrian-Iustin Georgevici, Benito Yard, Matthias Karck, Sevil Korkmaz-Icöz, Gábor SzabóAbstractThe major source of heart transplantation comes from brain-dead (BD) donors. However, brain death and myocardial ischemia/reperfusion injury during transplantation may lead to cardiac dysfunction and hemodynamic instability. A previous work demonstrated that pre-treatm...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusions: Interval exercise was well tolerated and preferred by participants with advanced ILD. PMID: 31625781 [PubMed - as supplied by publisher]
Source: Physiotherapy Theory and Practice - Category: Physiotherapy Authors: Tags: Physiother Theory Pract Source Type: research
Abstract Dilated cardiomyopathy (DCM) is the most common cause of heart failure (HF) in children, resulting in high mortality and need for heart transplantation. The pathophysiology underlying pediatric DCM is largely unclear, however there is emerging evidence that molecular adaptations and response to conventional HF medications differ between children and adults. In order to gain insight into alterations leading to systolic dysfunction in pediatric DCM, we measured cardiomyocyte contractile properties and sarcomeric protein phosphorylation in explanted pediatric DCM myocardium (N=8) compared to non-failing (NF)...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
In the current issue of the journal, Myers and colleagues 1 report on the combined use of impedance cardiography with cardiopulmonary stress testing (CPX) as an improved technique to risk stratify patients with heart failure. One thousand two hundred thirty-six consecutive patients referred for heart failure evaluation at a single institution underwent this testing. The composite endpoint included cardiac related death, hospitalization for heart failure, cardiac transplantation or LVAD implantation.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Brief Report Source Type: research
We present a retrospective review of 13 consecutive children who underwent implantation of VAD between 2001 and 2018 in our center. The median age was 12  years (1–17 years), weight was 45 kg (10–82 kg). Etiologies of heart failure were dilated cardiomyopathy (CMP) (n = 8), myocarditis (n = 2), ischemic CMP (n = 1), restrictive CMP (n = 1) and congenital heart disease (n = 1). Pre-implantation ECMO was used in 5, mechanical ventilation in 4, renal replacement therapy in 2 and IABP in 1. Devices used were: Berlin Heart EXCO...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research
Condition:   Steroid-Refractory Acute Graft Versus Host Disease Intervention:   Drug: T-Guard Sponsors:   Xenikos;   National Heart, Lung, and Blood Institute (NHLBI);   Blood and Marrow Transplant Clinical Trials Network;   National Cancer Institute (NCI);   National Marrow Donor Program Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewHeart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes.Recent FindingsBlack HT recipients have the highest risk for allograft failure an...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
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