Fixed-Dose Bempedoic Acid, Ezetimibe Combo for Statin Intolerance? Fixed-Dose Bempedoic Acid, Ezetimibe Combo for Statin Intolerance?
The fixed-dose combination of the complementary drugs is'potent and convenient,'researchers conclude, with statin intolerance potentially'a very nice niche. 'Medscape Medical News
Authors: Iqbal Z, Dhage S, Mohamad JB, Abdel-Razik A, Donn R, Malik R, Ho JH, Liu Y, Adam S, Isa B, Stefanutti C, Soran H Abstract Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel drugs that have been developed since the discovery of the PCSK9 protein in 2003. In addition to background statin treatment they reduce low density lipoprotein cholesterol (LDL-C) to unprecedented levels and have shown encouraging results in improving cardiovascular events. Concerns regarding the safety of PCSK9 inhibitors and very low LDL-C have somewhat been allayed after several longer-term prosp...
In conclusion, this preliminary pharmacogenetic study identifies thatCOQ2 gene polymorphism (rs4693075, G > C), notTNF- α gene polymorphism (rs1799724, C > T), is involved in causing statin-induced myopathy in Bangladeshi hyperlipidemic patients.
Publication date: Available online 18 October 2019Source: Canadian Journal of CardiologyAuthor(s): Dirk G. Struijk
Background and aims: Atrial fibrillation (AF) is a major cause of ischemic stroke; however, detailed clinical data and prognostic factors for stroke patients with AF are lacking in Korea. We aimed to investigate clinical information and factors associated with functional outcomes of stroke patients with AF from the Korean nationwide ATrial fibrillaTion EvaluatioN regisTry in Ischemic strOke patieNts (K-ATTENTION) database.Methods: From January 2013 to December 2015, consecutive clinical information from acute stroke patients with AF or history of AF was collected from 11 centers in Korea. Collected data included demographi...
Abstract NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation. PMID: 31626247 [PubMed - as supplied by publisher]
Changes in clinical guidelines have increased the number of people eligible to take statins. In many countries, the majority of people taking the drugs do so for primary prevention.
THURSDAY, Oct. 17, 2019 -- Many people who take cholesterol-lowering statins may not benefit from them, researchers say. Drugs like atorvastatin (Lipitor) and fluvastatin (Lescol) provide little value to people without heart disease, new research...
Title: For Kids With Genetic Condition, Statins May Be LifesaversCategory: Health NewsCreated: 10/16/2019 12:00:00 AMLast Editorial Review: 10/17/2019 12:00:00 AM