Heartburn drugs linked to fatal heart and kidney disease, stomach cancer

(Washington University in St. Louis) A study by researchers at Washington University School of Medicine in St. Louis and Veterans Affairs St. Louis Health Care System has linked long-term use of such popular heartburn drugs -- called proton pump inhibitors (PPIs) -- to fatal cases of cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. More than 15 million Americans have prescriptions for PPIs.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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The Pan-Mass Challenge fundraiser has raised a record-breaking $63 million for Dana-Farber Cancer Institute, the largest financial gift in the cancer hospital ’s history.  The PMC, which hosts a two-day, 192-mile bike ride to raise funding for Dana-Farber and The Jimmy Fund, has raised more than $717 million for the health system since 1980, helping to support development of 41 of 100 new FDA-approved cancer drugs.  “I am extremely grateful for th e generous support received from the Pan-Mass…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 18 October 2019Source: Molecular Aspects of MedicineAuthor(s): Lukas Valihrach, Peter Androvic, Mikael KubistaAbstractSuccessful treatment of cancer depends on early diagnosis and effective monitoring of patients’ response to therapy. Traditional tools based on tumor biopsies lack the sensitivity and specificity to capture cancer development in its early phases and are not applicable for continuous monitoring. To overcome these barriers, liquid biopsies have been introduced as a minimally invasive and cost-efficient means of diagnosis with high level of specificity and sensitivity. ...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Contributors : Y Li ; F Huang ; S ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlucose metabolism makes contributions to the development of pancreatic ductal adenocarcinoma (PDAC). Meanwhile, circular RNAs, a subset of noncoding RNAs, plays an important role in glucose metabolism and cancer progression. Analysis of low-glucose-treated and normal-glucose-treated MIA PaCa-2 cells from 6 samples (3 samples each group) was conducted. Results indicate insight into molecular signature of the pathogenesis of PDAC in abberant glucose metabolism.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
CONCLUSION: Radiolabelled PSMA imaging seems to be useful in analyzing glioma/glioblastoma. Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabelled PSMA in this setting and its possible position in the diagnostic flow-chart. PMID: 31625482 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
ConclusionsIn the appropriately selected patient, OSS in upper tract, bladder and urethral carcinoma has comparable oncological outcomes to radical surgery and with the additional benefit of improved quality of life.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionMRI has good diagnostic performance for assessing myometrial invasion in patients with endometrial cancer, especially in patients younger than 60 years old. Dynamic contrast-enhanced MRI and diffusion weighted imaging can help improve sensitivity and specificity for detecting myometrial invasion. MRI shows high specificity for detecting cervical invasion and lymph node metastases in endometrial cancer.
Source: Academic Radiology - Category: Radiology Source Type: research
Authors: Philipp-Dormston WG, Battistella M, Boussemart L, Di Stefani A, Broganelli P, Thoms KM Abstract Introduction: Actinic keratosis (AK) is a chronic skin condition that can be a precursor to cutaneous squamous cell carcinoma. AK can recur and patients are likely to undergo multiple treatments. It is important that AK lesions are managed appropriately, and that patients are involved in treatment decisions. Materials and methods: The Supporting Professional Expertise in AK (SPEAK) program aims to facilitate this patient-centered care by identifying patient needs and aiding healthcare practitioners (HCPs) in sel...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Garcia-Robledo JE, Barrera MC, Tobón GJ Abstract CRISPR/Cas evolved as an adaptive immune system in bacteria and archaea to inactivate foreign viral and plasmid DNA. However, the capacities of various CRISPR/Cas systems for precise genome editing based on sequence homology also allow their use as tools for genomic and epigenomic modification in eukaryotes. Indeed, these genetic characteristics have proven useful for disease modeling and testing the specific functions of target genes under pathological conditions. Moreover, recent studies provide compelling evidence that CRISPR/Cas systems could be u...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Authors: Megna B, Shaukat A PMID: 31623468 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
ari G Abstract Papillary thyroid microcarcinoma (PTMC) is defined by the World Health Organization as papillary cancer measuring 10 mm or less in diameter. Generally, PTMC shows an indolent clinical behavior with a good prognosis, although a minority of PTMC is characterized by an aggressive course. However, efforts to identify this aggressive subset of PTMC after surgery remain inconclusive. Several oncogenic pathways have been identified in thyroid cancer and have been applied translationally to improve prognosis and clinical management. In particular, the BRAFV600E mutation was found more frequently in large, a...
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research
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