Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy.

CONCLUSION: We report an increasing resistance to vancomycin coupled with daptomycin that occurred within approximately 3 days of receiving vancomycin and steadily increased until the infection was cleared with an alternative antibiotic therapy. This study reiterates the need for rapid, efficient and accurate detection of hVISA and VISA infections, especially in high-bacterial load, metastatic infections like bacteraemia. PMID: 31136294 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31136294?dopt=Abstract

Source: Journal of Medical Microbiology - May 27, 2019 Category: Microbiology Authors: Basco MDS, Kothari A, McKinzie PB, Revollo JR, Agnihothram S, Azevedo MP, Saccente M, Hart ME Tags: J Med Microbiol Source Type: research