A lignan and a lignan derivative from the fruit of Forsythia suspensa

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Chang Li, Qian Wei, Zhi-Hao Zou, Chen-Zhi Sun, Qin Wang, Gang Zhao, Xin-Jia Yan, Tian-Yi Yu, Chun-Li GanAbstractThe chemical investigation of a 95% ethanol extract of the fruit of Forsythia suspensa resulted in the isolation of one new lignan and one new lignan derivative, forsythialan E-F, along with two known lignans. Their structures were established based on extensive spectroscopic data analyses, including UV, IR, HRESIMS, 1D NMR and 2D NMR. Absolute configurations of 1-2 were determined by the CD method. In addition, compounds 1-2 were evaluated for their antiviral activity against the influenza A (H5N1) virus in vitro.Graphical abstractChemical investigation of the 95% ethanol extract of the fruit of Forsythia suspensa resulted in the isolation of one new lignan and one new lignan derivative, forsythialan E-F, along with two known ones. Their structures were established based on extensive spectroscopic data analyses, including IR, UV, HRESIMS, 1D NMR and 2D NMR. Absolute configurations of 1-2 were determined by CD method. In addition, compounds 1-2 were evaluated for their antiviral activity against influenza A (H5N1) virus in vitro.
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Publication date: Available online 11 July 2019Source: Veterinary MicrobiologyAuthor(s): Jiayun Yang, Zhengxiang Wang, Yingying Du, Yane Jia, Liang Wang, Shuai Xu, Qiyun ZhuAbstractDuring 2012―2015, six H5N1 avian influenza viruses were isolated from domestic birds and the environment around Qinghai Lake. Phylogenetic analysis of HA genes revealed that A/chicken/Gansu/XG2/2012 (CK/GS/XG2/12) belonged to clade 2.3.2.1a, while A/environment/Qinghai/1/2013 (EN/QH/1/13), A/chicken/Qinghai/QH1/2015 (CK/QH/QH1/15), A/chicken/Qinghai/QH2/2015 (CK/QH/QH2/15), A/chicken/Qinghai/QH3/2015 (CK/QH/QH3/15), and A/goose/Qinghai/QH6/201...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
The highly pathogenic H5N1 avian influenza virus (HPAIV) was first identified in China in 1996 [A/goose/Guangdong/1/1996 (Gs/GD)] and infected the human population in Hong Kong in 1997, with 18 recorded cases resulting in six deaths.1, 2 Since 2003, Gs/GD lineage H5N1 HPAIV infection in humans has been reported in 16 countries, with 860 laboratory-confirmed cases and 454 deaths as of 2018.3 Although human-to-human transmission has not been documented, H5N1 HPAIV has the potential to cause an influenza pandemic.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Abstract Avian influenza virus (AIV) is an extraordinarily diverse pathogen that causes significant morbidity in domesticated poultry populations and threatens human life with looming pandemic potential. Controlling avian influenza in susceptible populations requires highly effective, economical and broadly reactive vaccines. Several AIV vaccines have proven insufficient despite their wide use, and better technologies are needed to improve their immunogenicity and broaden effectiveness. Previously, we developed a "mosaic" H5 subtype hemagglutinin (HA) AIV vaccine and demonstrated its broad protection aga...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Publication date: 1 October 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 182Author(s): Taek Lee, Ga Hyeon Kim, Soo Min Kim, Keonyoung Hong, Younghun Kim, Chulhwan Park, Hiesang Sohn, Junhong MinAbstractIn the present study, we fabricated a label-free avian influenza (AIV H5N1) detection biosensor composed of a multi-functional DNA 3 way-Junction (3 W J) on a hollow Au spike-like nanoparticle (hAuSN) using a localized surface plasmon resonance (LSPR) method. To construct the multi-functional DNA (MF-DNA) as a bioprobe, the 3 W J was introduced. The proposed AIV detection bioprobe sh...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Articles Source Type: research
Abstract In the present study, we fabricated a label-free avian influenza (AIV H5N1) detection biosensor composed of a multi-functional DNA 3 way-Junction (3 W J) on a hollow Au spike-like nanoparticle (hAuSN) using a localized surface plasmon resonance (LSPR) method. To construct the multi-functional DNA (MF-DNA) as a bioprobe, the 3 W J was introduced. The proposed AIV detection bioprobe should contain three functionalities: target recognition, signal amplification, and connection to substrate. To achieve this goal, each piece of the DNA 3 W J was tailored to a hemagglut...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research
Routine surveillance and surveillance in response to influenza virus outbreaks in avian species in Vietnam in 2009–2013 resulted in the isolation of numerous H5N1 influenza viruses of clades 1.1.2, 2.3.2.1a, 2.3.2.1b, 2.3.2.1c, and 2.3.4.1. Consistent with other studies, we found that viruses of clade 2.3.2.1c were dominant in Vietnam in 2013 and circulated in the northern, central, and southern parts of the country. Phylogenetic analysis revealed reassortment among viruses of clades 2.3.2.1a, 2.3.2.1b, and 2.3.2.1c; in contrast, no reassortment was detected between clade 2.3.2.1 viruses and viruses of clades 1.1.2 o...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Influenza A virus (IAV) is one of the segmented negative-stranded RNA virus, which brings a potentially serious threat to public health and animal husbandry. Mast cells, a kind of immune cells, play an important role in both inherent and adaptive immune response. Previous studies indicated that mast cells support the productive replication of H1N1, H5N1 and H7N2. To date, the distinct of molecular mechanism behind the pathogenesis in mast cells among three different viruses was poorly understood. In the present study, we investigated the more profound genomic profiles for the first time and describe the dynamic change of g...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, the HPAI (H5N2) virus was isolated from a commercial duck farm, giving evidence of the emergence of the first natural reassortment event in domestic poultry in Egypt. The virus was derived as a result of genetic reassortment between avian influenza viruses of H5N8 and H9N2 subtypes circulating in Egypt. The exchange of the neuraminidase segment and high number of acquired mutations might be associated with an alteration in the biological propensities of this virus.
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
Background: A/H5N1 influenza virus has significant pandemic potential, and vaccination is the main prophylactic measure. This phase 2, randomized, observer-blind, multicenter study evaluated the safety and immunogenicity of two MF59-adjuvanted, cell culture-derived H5N1 (aH5N1c) vaccine formulations in healthy pediatric subjects 6 months to 17 years old. Methods: Subjects (N = 662) received 2 aH5N1c doses 3 weeks apart, containing either 7.5 μg (full dose) or 3.75 μg (half dose) hemagglutinin antigen per dose. Local reactions and adverse events (AEs) were assessed by age. Antibody responses were measured by hema...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
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