Recent Plateauing Seen in Prevalence of Diagnosed Diabetes

WEDNESDAY, May 29, 2019 -- The prevalence of diagnosed diabetes has plateaued during the last eight years, while the incidence has declined, according to a study published online May 28 in BMJ Open Diabetes Research&Care. Stephen R. Benoit,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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INTRODUCTION: Peripheral neuropathy is a major risk factor for falls in adults with diabetes. Innovative footwear devices which artificially manipulate the sensory environment at the feet, such as textured shoe insoles, are emerging as an attractive option...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
In this study, therefore, the underlying mechanism of methylglyoxal on osteoporosis was studied using both animal and cell models. In the animal model, rats were treated with either methylglyoxal or saline as control. In the cell model, the macrophage RAW264.7 was treated with methylglyoxal or vehicle control. Following the treatment, animal samples were harvested for micro-CT and real-time polymerase chain reaction analyses. Cell samples were harvested for MTT assay, RT-PCR, and Western Blotting analyses. In both animals and cell cultures, methylglyoxal was shown to induce osteoclastogenesis by increased gene expression o...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
The objective of this work was to investigate the effect of boletus polysaccharide (BPS) on diabetic hepatopathy in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats for the first time. The rats were fed with high-fat diet (HFD) for 4 weeks and induced with STZ by a single intraperitoneal injection to develop T2DM model. The HFD was given continually for another 4 weeks after diabetes induction, following the drugs of BPS (400 mg/kg bw/day) infused to stomach of rats once a day. After the administration, blood was drawn from the posterior orbital venous plexus of the inner canthus and the rats were then...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
It has been long known that the metabolic derangements of diabetes mellitus (both type 1 and type 2) could have important effects on the central nervous system, as assessed by many cognitive measures. This has been demonstrated in adults, as well as in children.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
Publication date: Available online 23 July 2019Source: The Journal of Foot and Ankle SurgeryAuthor(s): Timothy P. Shiraev, Benjamin A. Lipsky, Trevor M.Y. Kwok, David A. RobinsonABSTRACTGuidelines suggest culturing clinically uninfected bone at the margin after surgical resection for osteomyelitis, but little published evidence supports this procedure. To investigate whether culturing marginal bone after completing resection of infected bone affected antibiotic use or further surgical intervention, we collected data on sequential patients undergoing amputation for a foot infection at our tertiary care hospital between Janu...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 22 July 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Stefano Del Prato
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 22 July 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Oana P Zaharia, Klaus Strassburger, Alexander Strom, Gidon J Bönhof, Yanislava Karusheva, Sofia Antoniou, Kálmán Bódis, Daniel F Markgraf, Volker Burkart, Karsten Müssig, Jong-Hee Hwang, Olof Asplund, Leif Groop, Emma Ahlqvist, Jochen Seissler, Peter Nawroth, Stefan Kopf, Sebastian M Schmid, Michael Stumvoll, Andreas F H PfeifferSummaryBackgroundCluster analyses have proposed different diabetes phenotypes using age, BMI, glycaemia, homoeostasis model estimates, and islet autoantibodies. We ...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
ConclusionCarbonated drinks and fast food intake were positively associated with general/abdominal obesity, whereas low fat dairy products intake was inversely associated. Future cohort studies in this under-studied area are recommended.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
A Texas man with type 1 diabetes shares his story of overcoming hopelessness and founding a group for diabetics competing in Tough Mudder events.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
ConclusionsLiraglutide may down-regulate P4HA1 expression at least partly though CD36-JNK-AP1 pathway, thereby reducing myocardial fibrosis. Therefore, our study provides novel insight into the molecular mechanism and function of liraglutide in HG-mediated CFs.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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