Contributing factors and outcomes of burn-associated cholestasis

Although the outcomes of severe burn injuries have improved over recent decades, morbidity and mortality remain high: almost 40% of patients develop acute respiratory distress syndrome[1,2], up to 50% of patients develop acute kidney injury[3,4] and the mortality ranges from 15%[1,3,5] to 25-30%.[2,4] Liver necrosis and hepatic dysfunction after burn injuries have been reported since the late 1930s.[6] An autopsy series from the 1980s described increased liver size and lipid infiltrations after burn injuries.

Source: Journal of Hepatology - May 28, 2019 Category: Gastroenterology Authors: Christian de Tymowski, Fran çois Dépret, Sabri Soussi, Moreno Nabila, Thomas Vauchel, Maité Chaussard, Mourad Benyamina, Axelle Ferry, Alexandru Cupaciu, Marion Jully, Haikel Oueslati, Alexandre Fratani, Maxime Coutrot, Philippe Sogni, Maurice Mimoun, Source Type: research