Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging ‐Guided Treatment of Metastatic Melanoma

A sialic acid (SA) ‐targeted multivalent nanoplatform is presented for chemo ‐ and photodynamic therapy of the metastatic melanoma. The nanoplatform is constructed from phenylboronic acid‐grafted peptide nanotubes, which is further loaded with chemotherapeutics and photosensitizer. The nanoplatform can overcome the multiple biological barriers of solid tumors by recogniz ing SA on the surface of tumor cells for improved cancer therapy. AbstractTumor metastasis is considered a major cause of cancer ‐related human mortalities. However, it still remains a formidable challenge in clinics. Herein, a bioinspired multivalent nanoplatform for the highly effective treatment of the metastatic melanoma is reported. The versatile nanoplatform is designed by integrating indocyanine green and a chemother apeutic drug (7‐ethyl‐10‐hydroxycamptothecin) into phenylboronic acid (PBA)‐functionalized peptide nanotubes (termed as I/S‐PPNTs). I/S‐PPNTs precisely target tumor cells through multivalent interaction between PBA and overexpressed sialic acid on the tumor surface in order to achieve im aging‐guided combination therapy. It is demonstrated that I/S‐PPNTs are efficiently internalized by the B16‐F10 melanoma cells in vitro in a PBA grafting density–dependent manner. It is further shown that I/S‐PPNTs specifically accumulate and deeply penetrate into both the subcutaneous and lung metastatic B16‐F10 melanoma tumors. More importantly, I/S‐PPNT‐mediated combi...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research