Pseudomyogenic Hemangioendothelioma.

We report a case of PMHE on the left plantar surface of a 28-year-old woman. Histopathological examination of the resected specimen revealed spindle and epithelioid cells with plump and atypical nuclei proliferated in the dermis and subcutaneous fat tissue with marked fibroplasia. Both spindle and epithelioid cells had abundant eosinophilic cytoplasm. Neoplastic cells were diffusely positive for AE1/AE3, CK7, vimentin, CD31, FLI-1, ERG, and INI-1. From those findings, we made the diagnosis of PMHE. We describe the main points of differentiation between PMHE and diseases that have similar clinical and/or histopathological findings, including cellular dermatofibroma, spindle cell squamous cell carcinoma, epithelioid sarcoma, epithelioid hemangioendothelioma, epithelioid angiosarcoma, nodular or proliferative fasciitis, and granulomatous fibrosing granulation tissue due to a ruptured epidermal cyst. PMID: 31130564 [PubMed - in process]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research

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Conclusions/interpretationThese results demonstrate a fundamental role for AIM2 in energy metabolism, inflammation and insulin resistance. Our studies establish a novel link between the innate immunity proteins, AIM2 and p202, and metabolism.
Source: Diabetologia - Category: Endocrinology Source Type: research
This issue of the BJD has a focus on the effect of sunscreen on vitamin D synthesis. The topic remains a contentious issue in the context of skin cancer prevention and high rates of subnormal vitamin D levels in individuals living in temperate climates. Can sunscreen use prevent sunburn while still allowing adequate vitamin D synthesis? The answer from Young et al. is ‘yes’, with appropriate application of a sun protection factor (SPF) 15 sunscreen during a 1-week beach holiday. The new research data are timely given the findings of two reviews considering vitamin D status and sunscreen application that are als...
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editor's Choice Source Type: research
ConclusionThe radiomics features extracted from Gd-EOB-DTPA-enhanced MR images can be used to diagnose preoperative DPHCC. DPHCC is more likely to recur and cause death than HCC, suggesting that active postoperative management of patients with DPHCC is required.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
AbstractIntroductionBecause spermatocytic tumors of the testis are rare, only limited evidence exists regarding the malignant potential and the optimal management of localized and metastatic disease.Materials and methodsWe performed a systematic review through MEDLINE, EMBASE, Scopus, Cochrane Database of Systematic Reviews and Web of Science to identify reports including patients with testicular spermatocytic tumors.ResultsFrom originally 7863 studies, we extracted data of 146 patients of which 99% were treated with radical orchiectomy. Metastases in patients with initially localised disease were diagnosed in 7% of patien...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionAlthough classically, majority of studies have shown oncogenic roles of nucleoporins as genetic fusion partners in several types of leukemia, emerging evidence suggests that nucleoporins also modulate many cellular signaling pathways that are associated with several major non-hematological malignancies, such as carcinomas of skin, breast, lung, prostate and colon. Hence, nucleoporins are emerging as novel therapeutic targets in human tumors.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Abstract Hepatocellular carcinoma (HCC) is among the most frequently observed forms of cancer. MicroRNAs (miRNAs) are increasingly thought to play a key role in regulating the onset and progression of a wide range of cancer types. In the present report, we found that miR-455-5p expression was significantly decreased in both HCC patient tumor tissues and cell lines, and that this reduction in expression was linked to poorer patient outcomes. When we overexpressed miR-455-5p in HCC cell lines (Huh7 and HepG2), this was linked with impaired proliferation, colony formation, migration, and invasion. We further found th...
Source: Pathology, Research and Practice - Category: Pathology Authors: Tags: Pathol Res Pract Source Type: research
In Table  2 of the above-referenced article, the Desirable dose of Thyroid should have read “V50
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Tags: Erratum Source Type: research
A 70-year-old female patient with a history of locally advanced breast cancer presented with a 2-month duration of persistent gait imbalance. Ten years earlier, she initially received a diagnosis of an invasive ductal carcinoma of the right breast, triple negative, treated with mastectomy and axillary lymph node dissection, followed by adjuvant chemotherapy and postmastectomy radiation therapy. She had been followed up without evidence of disease until the present time. Magnetic resonance imaging of the brain demonstrated a lobulated enhancing mass measuring 3.6  × 2.4 × 3.6 cm involvin...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Penny Perkins, Ph.D. notified the International Journal of Radiation Oncology Biology and Physics that her name was included in the author line of the above meeting abstract. Dr. Perkins stated that she did not generate the statistics in the abstract, and was not aware of the submission. She requested removal of her name from the author line. Therefore, the author line of this abstract should be cited as follows:
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Tags: Erratum Source Type: research
This study's results suggest that both combination and sequential therapy of pd-FVIIa/FX and other bypassing agents are well tolerated and effective for the control of perioperative bleeding in haemophilia patients with high-responding inhibitors.
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
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