Perilipin 1 Expression Differentiates Liposarcoma from Other Types of Soft Tissue Sarcoma.

Perilipin 1 Expression Differentiates Liposarcoma from Other Types of Soft Tissue Sarcoma. Am J Pathol. 2019 May 21;: Authors: Straub BK, Witzel HR, Pawella LM, Renner M, Eiteneuer E, Hashani M, Schirmacher P, Roth W, Mechtersheimer G Abstract Lipid droplets, a morphological feature of adipocytic tumors, are strongly regulated by associated proteins of the perilipin/PAT-family. So far, the use of perilipins as markers for differential diagnosis of soft tissue tumors has only been studied in a few cases. The aim of the study was to investigate the expression of perilipins in 478 human soft tissue tumors as well as 60 respective normal tissues. All cases of well differentiated liposarcoma, over 90% of myxoid round cell liposarcoma and over 70% of pleomorphic liposarcoma, yet only in the well differentiated components of dedifferentiated liposarcoma were immunohistochemically positive for perilipin 1. All other types of soft tissue sarcoma were negative for perilipin 1. Perilipin 2 was more prominent in dedifferentiated and pleomorphic liposarcoma and nearly all other especially high-grade sarcoma. In well differentiated liposarcoma, lipoma or normal adipose tissue, perilipin 2 was virtually absent. In addition, long-term stimulation of adipogenesis in the liposarcoma cell line LiSa-2 restored perilipin 1 expression as exhibited in the source tumor. Furthermore, knock-down of perilipin 2 or 3 in LiSa-2 cells influenced lipid droplet number and size as well ...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research

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Condition:   Sarcoma, Clear Cell Intervention:   Drug: TSR-042 Sponsors:   Italian Sarcoma Group;   GlaxoSmithKline Not yet recruiting
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