Memory consolidation impairment induced by Interleukin-1 β is associated with changes in hippocampal structural plasticity.
Memory consolidation impairment induced by Interleukin-1β is associated with changes in hippocampal structural plasticity. Behav Brain Res. 2019 May 22;:111969 Authors: Herrera G, Calfa G, Schiöth HB, Lasaga M, Scimonelli T Abstract Pro-inflammatory cytokines, particularly Interleukin-1β (IL-1β), can affect cognitive processes such as learning and memory. The aim of this study was to establish whether the effect of IL-1β on contextual fear memory is associated with changes in hippocampal structural plasticity. We also studied the effect of α-melanocyte-stimulating hormone (α-MSH), a potent anti-inflammatory and neuro-protective peptide. Different groups of animals were implanted bilaterally in dorsal hippocampus (DH). After recovery they were conditioned for contextual fear memory and received the different treatments (vehicle, IL-1β, α-MSH or IL-1β + α-MSH). Memory was assessed 24 hs after conditioning and immediately after rats were perfused for dendritic spine analysis. Our results show that local hippocampal administration of IL-1β just after memory encoding induced impairment in contextual memory and a reduction in the total density of CA1 hippocampal dendritic spines, particularly the mature ones. α-MSH administration reversed the IL-1β induced changes. The results suggest that neuro-inflammation induced by IL-1β interferes with experience-dependent structural pl...
Authors: Hanewinkel R PMID: 31623003 [PubMed - in process]
Zum Kommentar von Prof. Reiner Hanewinkel zum Hot Topic-Thema „Raucherentwöhnung: E-Zigarette besser als klassische Nikotinersatzpräparate?“ Pneumologie 2019; 73: 336 – 337. Pneumologie. 2019 Oct;73(10):622 Authors: Pommer P PMID: 31623002 [PubMed - in process]
Authors: Schulz H, Karrasch S, Bölke G, Cyrys J, Hornberg C, Pickford R, Schneider A, Witt C, Hoffmann B PMID: 31623001 [PubMed - in process]
Leserbrief zu Schulz H, Karrasch S, Bölke G et al. Atmen: Luftschadstoffe und Gesundheit – Teil I. Pneumologie 2019; 73: 288 – 305. Pneumologie. 2019 Oct;73(10):617-619 Authors: Schnitzler A PMID: 31623000 [PubMed - in process]
Authors: Schöll N, Rohde GGU Abstract Pneumonia belongs to the most frequent and most deadly infectious diseases worldwide. It represents an increasing problem for the aging population. The incidence and mortality rises with every decade. The clinical presentation of pneumonia differs between elderly and younger patients. Multiple factors including functional status (self-dependency and immobilization), comorbidities, immunosenescence, nutritional status, swallowing disorders have to be accounted for. Pneumonia in the elderly has to be differentiated from nursing home acquired pneumonia. Diagnosis of pneumonia...
Perikardpunktion – Schritt für Schritt. Pneumologie. 2019 Oct;73(10):597-604 Authors: Ferrari MW PMID: 31622998 [PubMed - in process]
Authors: Raspe M, Rolling T, Leisse C, Fischer J, Lehmann C Abstract Infectious Diseases are a cross-sectional area connected to various medical disciplines and offer interested physicians multiple working opportunities. The spectrum of infectious diseases covers both out- and inpatient care as well as basic, clinical and epidemiological research. The need for infectious diseases specialists is increasing, thus career prospects are promising. Working conditions in infectious diseases are comparatively family-friendly. With this article we intend to arouse interest for working in the fascinating fields of infectious...
Authors: Bahmer T, Wälscher J, Fisser C, Kreuter M, Karg O, Böing S, Koczulla R, Raspe M PMID: 31622996 [PubMed - in process]
Lungengesundheit: Beruf als großer Risikofaktor? Pneumologie. 2019 Sep;73(9):e2 Authors: Simon A PMID: 31622984 [PubMed - in process]
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