Memory consolidation impairment induced by Interleukin-1 β is associated with changes in hippocampal structural plasticity.

Memory consolidation impairment induced by Interleukin-1β is associated with changes in hippocampal structural plasticity. Behav Brain Res. 2019 May 22;:111969 Authors: Herrera G, Calfa G, Schiöth HB, Lasaga M, Scimonelli T Abstract Pro-inflammatory cytokines, particularly Interleukin-1β (IL-1β), can affect cognitive processes such as learning and memory. The aim of this study was to establish whether the effect of IL-1β on contextual fear memory is associated with changes in hippocampal structural plasticity. We also studied the effect of α-melanocyte-stimulating hormone (α-MSH), a potent anti-inflammatory and neuro-protective peptide. Different groups of animals were implanted bilaterally in dorsal hippocampus (DH). After recovery they were conditioned for contextual fear memory and received the different treatments (vehicle, IL-1β, α-MSH or IL-1β + α-MSH). Memory was assessed 24 hs after conditioning and immediately after rats were perfused for dendritic spine analysis. Our results show that local hippocampal administration of IL-1β just after memory encoding induced impairment in contextual memory and a reduction in the total density of CA1 hippocampal dendritic spines, particularly the mature ones. α-MSH administration reversed the IL-1β induced changes. The results suggest that neuro-inflammation induced by IL-1β interferes with experience-dependent structural pl...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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