Effects of haloperidol on cognitive function and behavioural flexibility in the IntelliCage social home cage environment.

This study examined the effects of chronic administration of haloperidol in female C57BL/6 mice. As patients with schizophrenia often show perseverant behaviours and lack of behavioural flexibility, it is important to know whether the effect of haloperidol makes these traits worse. This study, therefore, was designed to evaluate the effects of haloperidol on the learning performance of mice using an automated home cage environment, the IntelliCage. Behavioural shuttling in the IntelliCage enabled us to assess learning in tasks including place discrimination learning and reversal place learning. In reversal place learning, spatial patterns of rewarded and non-rewarded places that mice had learned to discriminate were reversed, and the adaptability of mice to change the previously acquired place learning was measured. Haloperidol (1 mg/kg/day) reduced locomotor activity and water intake. Haloperidol impaired the cognitive flexibility of mice during reversal place learning rewarded by access to water but enhanced the rapid acquisition of behavioural flexibility when airpuff punishment was applied. PMID: 31136773 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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ConclusionsThe present study suggests that GM abnormalities in the LPAs, which can be detected during the early stage of illness, may underlie impaired verbal communication and positive symptoms in patients with schizophrenia spectrum psychosis.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
CONCLUSION: With emerging evidence of deleterious health effects of SB independent of PA, it is important to monitor SB in individuals with schizophrenia, particularly those presenting with negative symptoms. While the lack of treatment response for negative symptoms remains a challenge, effort should be made to reduce duration of SB. PMID: 31627166 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
In conclusion, increased structural connectivity of the slMFB may underlie delusional experiences of paranoia and grandiosity in SSD.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Children of mothers who had bacterial infections during pregnancy are more likely to develop mental health conditions like schizophrenia and bipolar disorder
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
ConclusionsWe show that our proposed approach performs comparably to a centralized approach while minimizing network traffic compared to multishot methods.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Authors: Kogan S, Ospina LH, Mittal VA, Kimhy D Abstract Neurocognitive difficulties are highly prevalent among people with schizophrenia and have been linked to increased inflammation, as well as dysfunction and disability. Poor neurocognitive functioning has also been documented in individuals at clinical high risk for psychosis (CHR) and a burgeoning literature point to alterations in inflammation markers in this population. However, there is limited information regarding the putative link between inflammation and neurocognition in CHR individuals, and the potential role of inflammation in the development of cog...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Conclusions: The findings show that neurocognition and social cognition are independent but related constructs. PMID: 31621495 [PubMed - as supplied by publisher]
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
Publication date: 17 October 2019Source: Cell, Volume 179, Issue 3Author(s): Rebecca L. Walker, Gokul Ramaswami, Christopher Hartl, Nicholas Mancuso, Michael J. Gandal, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jason L. Stein, Daniel H. GeschwindSummaryTissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain development is a critical epoch for neuropsychiatric disease susceptibility, we characterized the genetic control of the transcriptome in 201 mid-gestational human brains, identifying 7,962 expression quantitative trait loci (eQTL) and 4,635 spliceQTL (sQTL), including several thous...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 16 October 2019Source: Neuroscience ResearchAuthor(s): Georg Northoff, Hajime MushiakeAbstractNeural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like ...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Last year, Molecular Brain became the first BMC journal to introduce Micro Reports, an innovative way to quickly share research which would otherwise go unpublished as a full research paper. Micro Reports are short research summaries of up to 1200 words, ideal for publishing negative results, reproduced studies, smaller data sets which are still important but would not warrant a full research article, and brand new findings which should enter the public domain as soon as possible. Since the launch of this new article type, the journal has received 58 Micro Report submissions, with 24 publications to date. We’ve highl...
Source: BioMed Central Blog - Category: General Medicine Authors: Tags: Biology Open Access Publishing Molecular Brain neuroscience SfN19 Source Type: blogs
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