Central nucleus of the amygdala is involved in induction of yawning response in rats.

Central nucleus of the amygdala is involved in induction of yawning response in rats. Behav Brain Res. 2019 May 25;:111974 Authors: Kita I Abstract Yawning behavior is characterized by mouth opening accompanied by deep inspiration, as well as arousal response, and is often observed not only in states of boredom or drowsiness, but also in stressful emotional situations in humans and animals. These phenomena suggest that yawning response may be an emotional behavior, possibly through activation of the central nucleus of amygdala (CeA), which is a critical region for emotional responses. However, the involvement of the CeA in triggering yawning remains unknown. Here, we investigated whether neuronal activation of the CeA by microinjection of L-glutamate into the CeA is able to induce stereotyped yawning responses in anesthetized, spontaneously breathing rats. In addition, we assessed the effects of the CeA stimulation on the activation of oxytocin (OT) and CRF (corticotropin-releasing factor) neurons in the paraventricular nucleus of the hypothalamus (PVN), which is responsible for induction of yawning, using c-Fos immunohistochemistry. Microinjection of L-glutamate into the CeA causes an initial depressor response in the blood pressure and an arousal shift on the electrocorticogram followed by a single inspiration, which is the same as the typical pattern of the stereotyped yawning response induced by the PVN stimulation. In addition, the CeA stimulation a...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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ConclusionsThe use of abdominal instillation (with or without ropivacaine) did not change the effect of 6  h of NPT after sepsis in animals with open abdomen. The absence of adverse effects suggests that longer treatments should be tested.
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Timothy G Short, Douglas Campbell, Christopher Frampton, Matthew T V Chan, Paul S Myles, Tomás B Corcoran, Daniel I Sessler, Gary H Mills, Juan P Cata, Thomas Painter, Kelly Byrne, Ruquan Han, Mandy H M Chu, Davina J McAllister, Kate Leslie, Australian and New Zealand College of Anaesthetists Clinical Trials Network, M Shulman, S Wallace, C Farrington, W Gallagher, A DitoroSummaryBackgroundAn association between increasing anaesthetic depth and decreased postoperative survival has been shown in observational studies; however, evidence fro...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Helen F Galley, Nigel R Webster
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Faraj W Abdallah, Duminda N Wijeysundera
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Daniel I Sessler, Lijian Pei, Yuguang Huang, Edith Fleischmann, Peter Marhofer, Andrea Kurz, Douglas B Mayers, Tanja A Meyer-Treschan, Martin Grady, Ern Yu Tan, Sabry Ayad, Edward J Mascha, Donal J Buggy, Gang Tan, Zhiyong Zhang, Helen Keane, Maurice Stokes, Oliver Zotti, Michael Gnant, Silvia Perez-ProttoSummaryBackgroundThree perioperative factors impair host defence against recurrence during cancer surgery: the surgical stress response, use of volatile anaesthetic, and opioids for analgesia. All factors are ameliorated by regional anaesthesia...
Source: The Lancet - Category: General Medicine Source Type: research
Conclusion: This qualitative study offers insight into the patient's perspective of dental hygienists administering LA. Participants supported dental hygienists administering LA and appreciated the aspects of patient-centered care that this practice provided. Patient participants were unclear on educational requirements and training, but supported legislation allowing dental hygienists to administer LA. PMID: 31628175 [PubMed - in process]
Source: Journal of Dental Hygiene - Category: Dentistry Tags: J Dent Hyg Source Type: research
This article aims to evaluate the effectiveness, security, and performance difficulty of GIB in patients with pelvic and perineal oncological pain.MethodsA retrospective study between January 2016 and August 2017. Patients with poorly controlled pelvic oncological pain and patients experimenting opioid side effects in which GIB was performed ambulatory were included. Prognostic GIB was performed, under echographic and fluoroscopic control, with local anesthetic and corticoid. The neurolytic block was performed under fluoroscopic guidance. The technique was performed by the same anesthetist with pain management competence. ...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
AbstractConstipation, one of the adverse effects of opioid therapy with a major impact on quality of life, is still an unmet need for cancer patients, particularly those with an advanced and progressive disease, and for non-cancer patients chronically treated with opioids. The awareness of this condition is poor among healthcare providers, despite the recent publication of guidelines and consensus conferences. An early multidisciplinary approach of opioid-induced bowel dysfunction (OIBD), based on available therapies of proven effectiveness, could support clinicians in managing this condition, thus increasing patients &rsq...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Condition:   Cognitive Dysfunction Intervention:   Drug: ketamine sedation versus midazolam sedation Sponsors:   Universidad de Colima;   Instituto Mexicano del Seguro Social Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Zoster Without Complications Intervention:   Procedure: peripheral nerve block, inter fascial nerve block Sponsor:   Vinmec Healthcare System Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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