Activation of Adenosine A2a receptor accelerates and A2a receptor antagonist reduces intermittent hypoxia induced PC12 cell injury via PKC-KATP pathway.

In conclusion, our findings indicate that A2a receptor induced KATP expression by PKC activation and plays a role in accelerating PC12 cells injury induced by intermittent hypoxia exposure via A2a-PKC-KATP signal pathway mediated apoptosis.
PMID: 31129168 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - May 22, 2019 Category: Neurology Authors: Singh BL, Chen L, Cai H, Shi H, Wang Y, Yu C, Chen X, Han X, Cai X Tags: Brain Res Bull Source Type: research