Intelligent algorithms for genome research

(Technical University of Munich (TUM)) In order to find out which genes are responsible for diseases such as cancer or diabetes, scientists nowadays frequently resort to using machine-learning models. In order to give clinical researchers access to the latest algorithms, Professor Julien Gagneur from the Technical University of Munich (TUM) has set up a new repository called 'Kipoi' in collaboration with scientists from other universities and research institutes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Introduction: Life expectancy in women with breast cancer (BC) is 80% at 5 years. Age, medications, obesity, metabolic syndrome and diabetes increase cardiovascular risk. The Mediterranean diet (MeD) and low glycemic index (GI) diets, nevertheless, are protective. Therefore, we evaluated the effect of low-GI Mediterranean diet on cardiovascular risk factors in women treated for BC.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Introduction: Several lines of evidence confirm the role of the Mediterranean Diet (MedD) on primary and secondary prevention of chronic disease, such as diabetes, cardiovascular disease and cancer. Health-Related Quality of Life (HRQOL) includes physical, mental, emotional and social factors. A few studies evaluated the impact of the MedD on HRQOL. Therefore, we investigated the possible effect of adherence to the MedD on HRQOL in the DEDiCa Study (NCT02786875) participants, a study that evaluates the combined effect of diet, physical activity and vitamin D on the risk of recurrence in women diagnosed with breast cancer.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
AbstractBackgroundImmune checkpoint inhibitors, single or in combination, have recently become a cornerstone for the treatment of many malignancies. Ipilimumab, a CTLA-4 inhibitor, was initially FDA approved for treatment of unresectable or metastatic melanoma and subsequently in combination therapy for other cancers. Ipilimumab-induced hypophysitis (IH) risk of development varies in different studies between 0 and 17%. Furthermore, little is known on how to predict which patients will develop IH and its impact on efficacy of Ipilimumab and survival for these patients. Here we reviewed IH and its impact on progression-free...
Source: Pituitary - Category: Endocrinology Source Type: research
Healthy employees are productive employees. And their oral health is strongly connected to their overall health — so don’t overlook the importance of dental benefits. According to the Academy of General Dentistry, regular dental visits can help identify early signs of 120 diseases, including heart disease, diabetes, and several forms of cancer. In fact, 90 percent of systemic diseases have symptoms in and around the mouth. Dental benefits are a key factor in ensuring that we take care of our…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Abstract A significant obstacle to the study of human cancer biology and the testing of human specific immunotherapeutics is the paucity of translational models that recapitulate both the growth of human tumors and the functionality of human immune systems. Humanized mice engrafted with human hematopoietic stem cells (HSC) and patient-derived xenografts (PDX) enable preclinical investigation of the interactions between the human immune system and human cancer. We use immunodeficient non-obese diabetic (NOD, scid, gamma) NSG™ or NSG™-SGM3 mice as hosts for establishment of human immunity following HSC i...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Contributors : Wan Y Yang ; Pei S Rao ; Yong C Luo ; Hua K Lin ; Sing H Huang ; Jinn M Yang ; Chiou H YuhSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPrevious studies have identified liver cancer associated to NASH, diabetes, obesity, and some genetic risk factors. We want to investigate the synergism between diet and genetic risk factors in hepatocarcinogenesis using omics data of four background zebrafish in three types of diet. We found the fishes have more genetic risk factors at the same time, and have higher probability to accelerate cancer formation. Overfed and high fat diet...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Contributors : Wan Y Yang ; Pei S Rao ; Yong C Luo ; Hua K Lin ; Sing H Huang ; Jinn M Yang ; Chiou H YuhSeries Type : Expression profiling by arrayOrganism : Danio rerioPrevious studies have identified liver cancer associated to NASH, diabetes, obesity, and some genetic risk factors. We want to investigate the synergism between diet and genetic risk factors in hepatocarcinogenesis using omics data of four background zebrafish in three types of diet. We found the fishes have more genetic risk factors at the same time, and have higher probability to accelerate cancer formation. Overfed and high fat diet will increase the ch...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Danio rerio Source Type: research
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Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Authors: Sanal MG, Paul K, Kumar S, Ganguly NK Abstract Abstract: Artificial Intelligence (AI) and access to "Big Data" together with the evolving techniques in biotechnology will change the medical practice a big way. Many diseases such as type II diabetes will no longer be considered as a single disease. Many familiar cancers such as cancer of liver or pancreas will have hundreds of subtypes whose management will be very different. The way we think about diseases will change. It will no longer be possible for clinicians to make a diagnosis, remember the names of diseases, the names of drugs or managemen...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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