Use of inhaled steroids linked to reduced lung cancer risk in COPD patients

Study finds that risk of lung cancer was 30% lower in patients treated with inhaled steroids rather than beta agonists Related items fromOnMedica Cardio risk raised in people using long-acting bronchodilators COPD: ageing and multimorbidity, a new risk defined Inhaled corticosteroids linked to higher infection risk Lung experts call for ‘national plan for lung cancer’ COPD led to 3.2m deaths in 2015 worldwide
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Inhaled corticosteroids (ICSs) are often prescribed in patients with chronic obstructive pulmonary disease (COPD). Their impact on the risk of lung cancer, a leading cause of mortality in COPD patients, remains uncertain. Population-based linked administrative data between the years 1997 and 2007 from the province of British Columbia, Canada, were used to evaluate the association between lung cancer risk and ICS use in COPD patients. COPD was defined on the basis of receipt of three COPD-related prescriptions in subjects ≥50 years of age. Exposure to ICS was incorporated into multivariable Cox regression models usi...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking Original Articles: COPD Source Type: research
PMID: 30837158 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - Category: Respiratory Medicine Authors: Tags: Arch Bronconeumol Source Type: research
Background: Personalised therapy for COPD patients is debated. We investigated whether the rate of FEV1 decline differs between patients with and without ICS-containing medications, stratified by blood EOS level.Methods: The UK Clinical Practice Research Datalink (primary care records) and Hospital Episode Statistics (hospital records) were used to identify COPD patients with ≥2 FEV1 measurements ≥6 months apart. Follow-up started from first FEV1 until censoring at death, leaving database or first ICS-containing prescription (if not baseline ICS-containing user). The nearest blood EOS 2 years prior to the start of fo...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
International Journal of Cancer, EarlyView.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Rationale: This combination of fluticasone propionate (FP) and the long-acting β2-agonist salmeterol (Salm) can control the symptoms of asthma and COPD better than FP or Salm on their own and better than the combination of inhaled corticosteroids plus montelukast. FP/Salm has been shown to control symptoms of asthma and COPD better than a double dose of inhaled steroids. The patient in our report had a history of COPD, and suffered relapse of RP when given only steroids. It is possible that COPD history helps explain this patient's more difficult treatment course. Therefore, this combination may be more effective th...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
This study has investigated whether ICS use is associated with a lower risk of lung cancer.Materials and MethodsData from the Nord-Tr øndelag Health Study (HUNT2 Survey, 1995–1997) were merged with The Cancer Registry of Norway and Norwegian Cause of Death Registry. From a total of 65,215 participants, those with chronic airway inflammation, defined by FEV1% 
Source: Lung - Category: Respiratory Medicine Source Type: research
Background: Inflammation plays a central role in COPD and lung cancer carcinogenesis. Inhaled corticosteroids (ICS) reduce inflammation. We investigated whether ICS use are associated with a lower risk of lung cancer.Material and Methods: Data from the Nord-Trøndelag Health Study (HUNT2 Survey, 1995-1997) were merged with The Cancer Registry of Norway and Norwegian Cause of Death Registry. Of 65215 participants, those with chronic airway inflammation, defined by FEV1%
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Aspergillosis is responsible for a large spectrum of entities, from colonization to invasive pulmonary aspergillosis. Incidences of both lung cancer and pulmonary aspergillosis are growing. Because lung cancer is frequently associated to COPD (chronic obstructive pulmonary disease), to architectural abnormalities of bronchus and to a high exposure to corticosteroids, it may facilitate aspergillosis. However, these fungal complications in patients with lung carcinoma are poorly known. The main aims of our study were to analyze the frequency of aspergillosis in a cohort of lung cancer and to identify risk factors.A cohort of...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory Infections Source Type: research
Authors: Liu SF, Kuo HC, Lin MC, Ho SC, Tu ML, Chen YM, Chen YC, Fang WF, Wang CC, Liu GH Abstract Whether the use of inhaled corticosteroids (ICS) protects patients with chronic obstructive pulmonary disease (COPD) from lung cancer remains undetermined. In this retrospective nationwide population-based cohort study, we extracted data of 13,686 female COPD patients (ICS users, n = 1,290, ICS non-users, n = 12,396) diagnosed between 1997 and 2009 from the Taiwan's National Health Insurance database. These patients were followed-up until 2011, and lung cancer incidence was determined. Cox regression analysis was used...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
AbstractSupportive care and pharmacological treatment can improve the quality of life of people with end-stage chronic obstructive pulmonary disease (COPD) who cope on a daily basis with substantial physical, psychological, social and spiritual morbidity. Smoking cessation is the only intervention that reduces the rate of progression of COPD, but evidence-based drug treatments and non-pharmacological strategies can relieve symptoms and reduce the impact of exacerbations. People with severe COPD live with increasingly troublesome breathlessness and other symptoms such as fatigue, pain, sputum production and weight loss. As ...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
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