Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) in normal pressure hydrocephalus misinterpreted as atrophy: autopsy and radiological evidence.

We report a 67-year-old man with features of NPH but not diagnosed because radiographic findings were interpreted as cortical atrophy. Autopsy showed findings consistent with NPH and no neurodegenerative disease. The second patient with DESH underwent shunt surgery. Entrapped fluid diminished after the surgery, confirming this is not atrophy, but due to a CSF dynamic process. Patients with DESH have tight sulci adjacent to the entrapped fluid pockets, distinguishing it from cortical atrophy. 18F-Fluorodeoxyglucose PET can help differentiate DESH from cortical atrophy. PMID: 31130064 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31130064?dopt=Abstract

Source: Neurocase - May 26, 2019 Category: Neurology Authors: McCarty AM, Jones DT, Dickson DW, Graff-Radford NR Tags: Neurocase Source Type: research