Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature.

We describe a case of 76-year-old woman with glioblastoma multiforme (GBM) who developed HSE shortly after brain RT. Cerebrospinal fluid analysis (CSF) was normal and the diagnosis was driven by brain MRI and EEG. Prompt introduction of antiviral therapy improved the clinical picture. We highlight the importance of EEG and brain MRI for the diagnosis and suggest the possibility of antiviral profilaxys in oncologic patients who undergo brain RT.
PMID: 31125013 [PubMed - in process]

Source: Acta Bio-Medica : Atenei Parmensis - May 22, 2019 Category: General Medicine Authors: Mutti C, Curti E, Ciliento R, Melpignano A, Florindo I, Zinno L, Sasso E, Parrino L, Pavesi G, Vaudano AE Tags: Acta Biomed Source Type: research