Primary central nervous system lymphoma following immunotherapy for metastatic melanoma.

CONCLUSION: While immunotherapy cannot be unequivocally incriminated in primary central nervous system lymphoma, this case raises many questions about the imputability of immunotherapy in the occurrence of secondary cancers, including lymphomas. PMID: 31122751 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research

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Conclusion: The majority of children with RB in Uganda present clinically with leucokoria, and their parents or guardians seek medical intervention at a later stage. Moreover, there was a noticeably significant lag period for the patients to begin treatment after the diagnosis was done. PMID: 31316824 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Authors: Lorenzo-González M, Torres-Durán M, Barbosa-Lorenzo R, Provencio-Pulla M, Barros-Dios JM, Ruano-Ravina A Abstract Introduction: Lung cancer is the most important cause of cancer mortality. It is a multifactorial disease with multiple risk factors, including residential radon exposure. Areas covered: The aim of this paper was to review the epidemiology of residential radon exposure and its impact on lung cancer risk. While tobacco is the main risk factor of lung cancer, residential radon is the first cause in never-smokers and the second in ever-smokers. Moreover, the synergistic effect betwee...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
Authors: Grossmann M, Ramchand SK, Milat F, Vincent A, Lim E, Kotowicz MA, Hicks J, Teede HJ Abstract INTRODUCTION: Representatives appointed by relevant Australian medical societies used a systematic approach for adaptation of guidelines (ADAPTE) to formulate clinical consensus recommendations on assessment and management of bone health in women with oestrogen receptor-positive early breast cancer receiving endocrine therapy. The current evidence suggests that women receiving adjuvant aromatase inhibitors and pre-menopausal woman treated with tamoxifen have accelerated bone loss and that women receiving adjuvant a...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Publication date: Available online 18 July 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Karolina Rogala-Koziarska, Łukasz Samluk, Katarzyna A. NałęczAbstractPlasma membrane transporter SLC6A14 transports all neutral and basic amino acids in a Na/Cl – dependent way and it is up-regulated in many types of cancer. Mass spectrometry analysis of overexpressed SLC6A14–associated proteins identified, among others, the presence of cytosolic heat shock proteins (HSPs) and co-chaperones. We detected co-localization of overexpressed and native SLC6A14 with HSP90-beta and HSP70 (HS...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
In this study, we investigated the effects of stress on immunosurveillance against cancer cells using a previously established examination stress model. We showed that the cancer killing activity (CKA) of granulocytes (also known as polymorphic nuclear cells, PMNs) is sharply reduced during examination stress stimulation in some donors who are psychologically sensitive to examination stress, with the concentration of plasma stress hormones (cortisone, epinephrine, and norepinephrine) increasing accordingly. The effects of stress hormones on immune cell CKA were also investigated under two in vitro co-incubation conditions,...
Source: Stress - Category: Research Tags: Stress Source Type: research
Publication date: 1 September 2019Source: Life Sciences, Volume 232Author(s): Meng Wang, Haibin Wu, Mingyue Duan, Ying Yang, Guoxia Wang, Fengyu Che, Bailing Liu, Wei He, Qiao Li, Liyu ZhangAbstractAimsCD123 represents an important acute myeloid leukemia (AML) therapeutic target. CD123 aptamers may potentially serve as tumor-homing ligands with excellent affinity and specificity for AML targeted therapy, but their complexity, laborious preparation and nuclease digestion limited pharmacological application. The aim of this study was to develop the first CD123 thioaptamer to overcome these obstacles.Main methodsFlow cytometr...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 July 2019Source: Journal of Environmental Chemical EngineeringAuthor(s): Keshaw R. Aadil, Neha Pandey, Solange I. Mussatto, Harit JhaAbstractThe present study uncovers the in-vitro cytotoxicity, sensing properties, catalytic and antibacterial activity of lignin functionalized silver nanoparticles (AGNPs). Fabricated AGNPs were characterized using UV-visible spectroscopy, particle size, X-ray diffraction (XRD) and Transmission Electron Microscopic (TEM) analyses. The typical surface plasmon resonance peak of AGNP was recorded at 410 nm, as confirmed from UV-visible spectrum. Synt...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Purpose of review Brain tumors are composed of primary tumors of the central nervous system, such us glioblastoma (GBM), and secondary metastatic tumors, such as melanoma, non-Hodgkin lymphoma as well as lung and breast cancers. Brain tumors are highly deadly, and unfortunately not many improvements have been achieved to improve the survival of patients with brain tumors. Chemoradiation resistance is one of the most clinically relevant challenges faced in patients with brain tumors. The perivascular niche is one of the most relevant microenvironment hubs in brain tumors. The understanding of the cellular crosstalk establ...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: CANCER BIOLOGY: Edited by Pierre Hainaut Source Type: research
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