ORION-2: Sustained LDL Reduction With Inclisiran in Homozygous FH ORION-2: Sustained LDL Reduction With Inclisiran in Homozygous FH

Prolonged effect plus marked LDL-cholesterol lowering may offer patients with familial hypercholesterolemia a convenient twice-a-year treatment option, a pilot study suggests.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news

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Authors: Iqbal Z, Dhage S, Mohamad JB, Abdel-Razik A, Donn R, Malik R, Ho JH, Liu Y, Adam S, Isa B, Stefanutti C, Soran H Abstract Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel drugs that have been developed since the discovery of the PCSK9 protein in 2003. In addition to background statin treatment they reduce low density lipoprotein cholesterol (LDL-C) to unprecedented levels and have shown encouraging results in improving cardiovascular events. Concerns regarding the safety of PCSK9 inhibitors and very low LDL-C have somewhat been allayed after several longer-term prosp...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
This study evaluates the effects of a chemically characterized polyphenolic extract of H. sabdariffa (HSE) in an experimental model of diet-induced obesity (DIO) in mice. HSE was administered daily by oral gave for 42 days. HSE reduced weight increase in high fat diet (HFD)-fed mice, and improved glucose tolerance, insulin sensitivity and normalized LDL/HDL cholesterol ratio. It also enhanced the inflammatory state in the liver, reducing the expression of different adipokines and proinflammatory mediators, and reinforced gut integrity by increasing the expression of mucins and proteins involved in the maintenance of mucosa...
Source: Food Research International - Category: Food Science Source Type: research
What you eat can help with high blood pressure, high cholesterol, pre-diabetes, though many people pay little heed.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Publication date: Available online 17 October 2019Source: Food ChemistryAuthor(s): Wael N. Hozzein, Ahmed M. Saleh, Talaat H. Habeeb, Mohammed A.M. Wadaan, Hamada AbdElgawadAbstractA high level of serum cholesterol is a major cause of atherosclerosis. Fenugreek is a well-known hypocholesterolaemic agent with amazing phytochemical composition. Due to its impact on plant metabolism, CO2 enrichment was tested as a strategy to support functional values in fenugreek seeds. Phytochemical composition and biological activities of three fenugreek cultivars (G2, G6 and G30) grown under ambient (aCO2, 400 μmol mol-1) and elevated ...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 17 October 2019Source: Biosensors and BioelectronicsAuthor(s): Xia Li, Fei Yin, Xiaowen Xu, Liqi Liu, Qingwang Xue, Lin Tong, Wei Jiang, Chenzhong LiAbstractThe sensitive imaging of telomerase RNA (TR) in living cells is crucial for improved guidance in cancer clinical diagnosis because its expression level is closely related to malignant diseases. The efficient delivery of multiple nucleic acid probes to target cells is critical for nucleic acid-based methods to successfully image low-abundance TR in living cells. While novel nanomaterials enhance delivery efficiency, uncontrolled loadin...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
In conclusion, among US adults ≥40 years, olfactory dysfunction is associated with anthropometric and glucose and lipid levels, with associations varying by sex and age group.
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: Available online 18 October 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Marta Targosz-Korecka, Anita Wnętrzak, Anna Chachaj-Brekiesz, Agnieszka Gonet-Surówka, Agata Kubisiak, Anna Filiczkowska, Marek Szymoński, Patrycja Dynarowicz-LatkaAbstractIn this paper, systematic studies concerning the influence of selected oxysterols on the structure and fluidity of human erythrocyte membrane modeled as Langmuir monolayers have been performed. Three oxidized cholesterol derivatives, namely 7α-hydroxycholesterol (7α-OH) 7β-hydroxycholesterol (7β-OH) and 7-k...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
In conclusion, this preliminary pharmacogenetic study identifies thatCOQ2 gene polymorphism (rs4693075, G  >  C), notTNF- α gene polymorphism (rs1799724, C  >  T), is involved in causing statin-induced myopathy in Bangladeshi hyperlipidemic patients.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 October 2019Source: Revista Española de Cardiología (English Edition)Author(s): Luis M. Rincón, Marcelo Sanmartín, Gonzalo L. Alonso, José Antonio Rodríguez, Alfonso Muriel, Eduardo Casas, Miguel Navarro, Alejandra Carbonell, Carla Lázaro, Sara Fernández, Paz González, Macarena Rodríguez, Manuel Jiménez-Mena, Covadonga Fernández-Golfín, Amparo Esteban, María Laura García-Bermejo, José L. ZamoranoAbstractIntroduction and objectivesTo evaluate whether a genetic risk score (GRS)...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
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