Distinct Roles of the NAD+-Sirt1 and FAD-LSD1 Pathways in Metabolic Response and Tissue Development

Publication date: Available online 28 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Mitsuyoshi Nakao, Kotaro Anan, Hirotaka Araki, Shinjiro HinoVarious nutritional signals are transduced by two epigenetic pathways: NAD-dependent sirtuin Sirt1 (NAD+-Sirt1) deacetylase and flavin adenine dinucleotide–dependent lysine-specific demethylase 1 (FAD-LSD1). These pathways are controlled by dietary vitamins and nutrient-responsive hormones such as glucocorticoids and insulin, resulting in endocrine–metabolism–epigenome cooperation in adipocyte and skeletal muscle development.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research