Astragalus Polysaccharide Eases G1 Phase-Correlative Bystander Effects through Mediation of TGF- β R/MAPK/ROS Signal Pathway After Carbon Ion Irradiation in BMSCs.

In this study, APS decreased proliferation and colony rate of bystander cells by inducing cell cycle arrest at G1 phase via extrinsic and intrinsic DNA damage. Regarding mechanism, APS inhibited mitogen-activated protein kinase (MAPK) signal pathway by down-regulating the expression of the key proteins, phosphorylated JNK (p-JNK), phosphorylated ERK (p-ERK) but not phosphorylated P38 (p-P38), and down-regulating their downstream function protein and molecule, cyclooxygenase-2 (COX-2) and reactive oxygen species (ROS). Moreover, in bystander cells, APS inhibits expression of transforming growth factor β receptor II (TGF- β R II), a cell membrane receptor, resulting in lower ROS production and secretion via TGF- β R-JNK/ERK-COX-2/ROS not P38 signaling. They gave a hint that the decreased RIBE damage induced by APS treatment involved TGF- β R-JNK/ERK-COX-2/ROS down-regulation. PMID: 31122040 [PubMed - in process]
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research