4-Locus high-resolution HLA allele and haplotype frequencies in Amerindians from Costa Rica.

4-Locus high-resolution HLA allele and haplotype frequencies in Amerindians from Costa Rica. Hum Immunol. 2019 May 22;: Authors: Arrieta-Bolaños E, Madrigal-Sánchez JJ, Stein JE, Salazar-Sánchez L, Madrigal JA, Marsh SGE, Shaw BE Abstract A total of 125 Costa Ricans of Amerindian descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 8.26%. A deviation from Hardy-Weinberg Equilibrium was detected at the DRB1 locus (p = 0.099). The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Amerindians" and the identifier AFN3608. PMID: 31128907 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research