cDC1s: New Orchestrators of Tissue Innate Immunity.

cDC1s: New Orchestrators of Tissue Innate Immunity. Trends Immunol. 2019 May 24;: Authors: Del Fresno C, Sancho D Abstract Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for neutrophil recruitment via the production of VEGF-α. These results reveal a crucial function for cDC1s beyond antigen presentation. PMID: 31133464 [PubMed - as supplied by publisher]
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Tags: Trends Immunol Source Type: research