Host immunomodulation by ascorbic acid ameliorates oxidative stress in caprine Pediculosis - A Pilot Study

Publication date: Available online 28 May 2019Source: Small Ruminant ResearchAuthor(s): Y. Ajith, Umesh Dimri, Arumugam Gopalakrishnan, Gopinath Devi, Nellooran Junaid, E. MadheshAbstractPediculosis is the most common and economically significant dermatological condition in goats caused mainly by the chewing lice, (Damalinia (Bovicola) caprae. Clinically, it is associated with varying levels of hypersensitivity skin reactions and its clinico-pathology is less explored. The present study aimed to investigate the immuno-oxidative pathology of chewing lice infestation in goats vis-à-vis immunomodulatory potential of two standard antioxidants (Ascorbic acid and N- acetyl cysteine) as an adjunct therapy in its management. Thirty two goats were divided into four groups of eight animals each; Group I, II and III included lice infested and Group IV included healthy control. Group I animals underwent ivermectin therapy (200 µg/kg SC single dose) only; whereas group II and group III animals received N-acetyl cysteine (12 mg/kg B. wt.) and Ascorbic acid (20 mg/kg B. wt.), respectively, orally once daily for 14 days along with ivermectin therapy (200 µg/kg SC single dose). The haematological (Hb, TEC, TLC and DLC), oxidant-antioxidant (LPO, GSH, TAC, SOD and catalase activity) and immunological (TNF-α, IL-10, TGF-β1, Th1/Th2 ratio and immunosuppression ratio) parameters were studied on day 0 (Before therapy) and day 28 (Post therapy). Animals with pediculosis revealed Th2 do...
Source: Small Ruminant Research - Category: Zoology Source Type: research