Endocrine implications of bariatric surgery: a review on the intersection between incretins, bone, and sex hormones
Gastric bypass surgery leads to dramatic weight loss and improvement in insulin resistance to the point of the resolution of type 2 diabetes in a majority of cases. These improvements in insulin sensitivity appear to be weight loss independent and occur immediately after bariatric surgery. The focus of the current review will be to summarize how the physiological changes that have been shown to arise from sustained weight loss after bariatric surgery affect other interrelated endocrine processes such as bone remodeling and improve obesity ‐related hypogonadal dysfunction. AbstractBariatric surgery is now the most widely used intervention for the treatment of human obesity. A large body of literature has demonstrated its efficacy in sustained weight loss and improvement in its associated comorbidities. Here, we review the effect of bariatric surgery in gut hormone physiology, bone remodeling and the reproductive axis. Rapid improvements in insulin release and sensitivity appear to be weight loss independent and occur immediately after surgery. These effects on pancreatic beta cells are mostly due to increased gut hormone secretion due to augmented nutrient delivery to the small intestine. Bone remodeling is also affected by gut hormones. Phenotypic skeletal changes observed in mice deficient in GLP ‐1 or GIP suggest that increased incretins may improve bone density. However, these positive effects may be counterbalanced by the association between weight loss and a reductio...
Publication date: Available online 24 September 2020Source: Microvascular ResearchAuthor(s): Lauren Van Hove, Kirsten R. Kim, Denise M. Arrick, William G. Mayhan
Authors: Clapp B, Liggett E, Ma C, Castro C, Montelongo S, Van Noy K, Dilday J, Tyroch A Abstract Background: Many bariatric surgeons test the anastomosis and staple lines with some sort of provocative test. This can take the form of an air leak test with a nasogastric tube with methylene blue dye or with an endoscopy. The State Department of Health Statistics in Texas tracks outcomes using the Texas Public Use Data File (PUDF). Methods: We queried the Texas Inpatient and Outpatient PUDFs for 2013 to 2017 to examine the number of bariatric surgeries with endoscopy performed at the same time. We used the Interna...
Abstract OBJECTIVE: to understand the experience of discrimination perceived by overweight women. METHODS: a qualitative research conducted at an outpatient clinic in Salvador, Bahia, where eleven women were interviewed. The interviews were transcribed and submitted to thematic content analysis. RESULTS: the analysis of the statements expressed three categories: Suffering discrimination in different social contexts: denounced disrespect, hostility, veiled and/or explicit exclusion, prejudice, injustice and insults lived in public transport, at work, in the family environment, in social events and commerc...
CONCLUSIONS: the educational intervention mediated by booklet was effective in improving knowledge and attitude when compared to verbal guidance. Thus, it can be replicated during the preoperative preparation. PMID: 32965318 [PubMed - in process]
Publication date: Available online 24 September 2020Source: American Journal of Kidney DiseasesAuthor(s): Zhi Yu, Morgan E. Grams, Chiadi E. Ndumele, Lynne Wagenknecht, Eric Boerwinkle, Kari North, Casey M. Rebholz, Edward L. Giovannucci, Josef Coresh
New York University researchers explore variation in insulin prices and out-of-pocket costs for people with and without health insurance, and how those with inadequate coverage struggle to afford insulin. An important factor in ensuring affordable access to insulin is living in a state that has expanded Medicaid.
Authors: Li L, Sun W, Han M, Ying Y, Wang Q Abstract BACKGROUND Early and rapid identification of severe coronavirus disease 2019 (COVID-19) cases is important. The present study aimed to investigate the predictors of disease severity and thus determine the trends for disease progression early. MATERIAL AND METHODS Patients with COVID-19 were recruited from Fuyang Second People's Hospital from January to February 2020. Patients' demographic, epidemiological, and clinical data were collected, and the relationships between these variables and disease severity were analyzed. RESULTS A total of 158 cases were included ...
Just as the thread title states. I currently utilize the Kimberly-Clark/halyard/Avanos machine. It is what I used in fellowship and when started in practice a little more than 10 years ago I got the same one. I really like cooled RFA in the lumbar spine especially for obese patients or patients with tough anatomy. It is great to be able to come in perpendicular because you get a very true view of the junction being squared up and you are obliqued so you get anterior enough without... RFA machine shopping: needs: perpendicular lesion ability and multilesion ability
Publication date: November–December 2020Source: Heart &Lung, Volume 49, Issue 6Author(s): Jamie L. Jackson, Kristen R. Fox, Jennifer Cotto, Tondi M. Harrison, Andrew H. Tran, Sarah A. Keim
Condition: Covid19 Intervention: Drug: Famotidine 20 MG Sponsor: drpykessupplements.com Not yet recruiting
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