TREM2 Attenuates A β1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling.

In conclusion, TREM2 promoted clearance of Aβ1-42 by BV-2 cells and restored BV-2 cell viability from Aβ1-42-mediated neuroinflammation by downregulating TLRs. These findings suggest that TREM2 may be a target for LOAD therapy. PMID: 31134514 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31134514?dopt=Abstract

Source: Neurochemical Research - May 26, 2019 Category: Neuroscience Authors: Long H, Zhong G, Wang C, Zhang J, Zhang Y, Luo J, Shi S Tags: Neurochem Res Source Type: research