Enzyme Linked to Most Common Brain Tumor

Higher levels of the enzyme kallikrein 6 (KLK6) are associated with glioblastoma multiforme, the most common type of brain tumor, according to a new study from researchers at the Mayo Clinic.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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Conditions:   Brain Tumor;   Brain Cancer Interventions:   Diagnostic Test: PET/MR with [18F]PARPi;   Drug: [18F]PARPi Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(University of California - San Diego) According to a new Cell study, extra DNA scooped up and copied alongside cancer-causing genes helps keep tumors going -- elements that could represent new drug targets for brain tumors and other cancers notoriously difficult to treat.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Ivy Brain Tumor Center) The Ivy Brain Tumor Center at the Barrow Neurological Institute, today announced a strategic collaboration with SonALAsense to develop and test a new, non-invasive drug-device combination, sonodynamic therapy (SDT), for recurrent glioblastoma through a Phase 0/2 clinical trial. Details of the study, as well as the results of two other clinical trials will be announced by Dr. Nader Sanai, director of the Ivy Brain Tumor Center, at the 2019 Society of Neuro-Oncology Annual Meeting (SNO) in Phoenix, Ariz. on Nov. 22.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractPediatric brain tumors are the leading cause of cancer-related death in children. Recent advances in sequencing techniques, and collaborative efforts to encode the mutational landscape of various tumor subtypes, have resulted in the identification of recurrent mutations that may present as actionable targets in these tumors. A number of molecularly targeted agents are approved or in development for the treatment of various tumor types in adult patients. Similarly, these agents are increasingly being incorporated into pediatric clinical trials, allowing for a targeted approach to treatment. However, due to the genet...
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
Cancers, Vol. 11, Pages 1838: Risk of Optic Pathway Glioma in Neurofibromatosis Type 1: No Evidence of Genotype–Phenotype Correlations in A Large Independent Cohort Cancers doi: 10.3390/cancers11121838 Authors: Melloni Eoli Cesaretti Bianchessi Ibba Esposito Scuvera Morcaldi Micheli Piozzi Avignone Chiapparini Pantaleoni Natacci Finocchiaro Saletti The occurrence of optic pathway gliomas (OPGs) in children with neurofibromatosis type 1 (NF1) still raises many questions regarding screening and surveillance because of the lack of robust prognostic factors. Recent st...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Xu CH, Xiao LM, Zeng EM, Chen LK, Zheng SY, Li DH, Liu Y Abstract Gliomas are aggressive type of brain tumors and cause significant human mortality world over. The frequent relapses, development of drug resistance, the adverse effects of the chemotherapy and dearth of the therapeutic targets form the major hurdles in glioma treatment. Several studies suggest that microRNAs (miRs) are involved in the development and progression of different cancers. Herein, the therapeutic potential of miR-181 was explored in human glioma cells. The results showed that miR-181 is significantly downregulated in human glioma ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
(Jackson Laboratory) The Glioma Longitudinal Analysis (GLASS) Consortium characterized diffuse glioma cells both before and after therapy to characterize how they change and why this form of malignant brain cancer is so difficult to treat. The findings provide a foundation for further research and the opportunity for the clinical community to predict the effectiveness of newly developed treatments.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
(NIH/National Center for Advancing Translational Sciences (NCATS)) Researchers have devised a new, promising plan of attack against deadly childhood brain cancers called diffuse midline gliomas (DMG). NCATS and Stanford University scientists and their colleagues showed that combining two drugs killed DMG patient cells grown in the laboratory and in animal models. The drugs countered the effects of a genetic mutation that causes the diseases. Their studies also uncovered an unrecognized vulnerability in the cancer cells that scientists may be able to exploit.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 18 November 2019Source: Cancer GeneticsAuthor(s): Michael Evenson, Chunyu Cai, Vishwanathan Hucthagowder, Samantha McNulty, Julie Neidich, Shashikant Kulkarni, Sonika DahiyaAbstractEpendymomas are neuroepithelial tumors that differentiate along the ependymal cell lineage, a lining of the ventricles of the brain and the central canal of the spinal cord. They are rare in adults, but account for 9% of brain tumors in children, where they usually have an aggressive course. Efficient stratification could lead to improved care but remains a challenge even in the genomic era. Recent studies prop...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
The ability of self-replicating oncolytic viruses (OVs) to preferentially infect and lyse cancer cells while stimulating anti-tumor immunity of the host strongly indicates its value as a new field of cancer therapeutics to be further explored. The emergence of Zika virus (ZIKV) as a global health threat due to its recent outbreak in Brazil has caught the attention of the scientific community and led to the discovery of its oncolytic potential for the treatment of glioblastoma multiforme (GBM), the most common and fatal brain tumor with poor prognosis. Herein, we evaluate the neurotropism of ZIKV relative to the receptor ty...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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