Higher BMI in Male Teens Tied to Cardiomyopathy in Adulthood
TUESDAY, May 28, 2019 -- Increased body mass index (BMI) in adolescence is associated with an increased risk for cardiomyopathy in adulthood among men, according to a study published online May 28 in Circulation. Josefina Robertson, M.D., from the...
Heart failure (HF) with reduced contractile function is a common and lethal syndrome in which the heart cannot pump blood to adequately meet bodily demands, resulting in high mortality despite the current standard of care. In modern societies, the most common drivers of HF are ischemic heart disease and hypertension. However, in a substantial subset of cases, patients present with dilated and poorly contracting hearts without evidence of common inciting stressors, a syndrome called dilated cardiomyopathy (DCM). Genome sequencing has identified a host of deleterious germline variants in key cardiomyocyte genes as causes of ...
We report that deletion of Lmna in cardiomyocytes in mice leads to severe cardiac dysfunction, conduction defect, ventricular arrhythmias, fibrosis, apoptosis, and premature death within 4 weeks. The phenotype is similar to LMNA-associated cardiomyopathy in humans. RNA sequencing, performed before the onset of cardiac dysfunction, led to identification of 2338 differentially expressed genes (DEGs) in Lmna-deleted cardiomyocytes. DEGs predicted activation of bromodomain-containing protein 4 (BRD4), a regulator of chromatin-associated proteins and transcription factors, which was confirmed by complementary approaches, includ...
Publication date: Available online 5 August 2020Source: Meta GeneAuthor(s): Mitali Kapoor, Soumi Das, Amitabh Biswas, Prit Benny Malgulwar, Kiranmala Devi, Sandeep Seth, Balram Bhargava, Vadlamudi R. Rao
CONCLUSIONS: We found that the intramyocardial transplanted hUC-MSCs engrafted and partially transdifferentiated into cardiomyocytes, reduced scar formation, and induced angiogenesis through the association of pro/anti-inflammatory macrophages. PMID: 32778240 [PubMed - in process]
Publication date: November 2020Source: Pharmacological Research, Volume 161Author(s): Irshad Ahmad, Muddasarul Hoda
Which cardiac conditions are disqualifying for kids who play sports? From hypertrophic cardiomyopathy to heart transplant, Mayo Clinic's Jonathan Johnson and Bernard Gersh have answers that may surprise you.Mayo Clinic
Heart failure (HF) is a multifaceted, etiology varied clinical syndrome leading to high levels of morbidity and mortality worldwide. The prevalence of HF continues to rise following 65 years, affecting almost 1 in 100 people. Atherosclerosis and concurrent ischemic heart disease are the most prevalent cause of HF in the developed world. Hypertension (which conducting to degenerated hypertrophy that can lead to cardiomyopathy and HF), dilated non-ischemic cardiomyopathy and genetic factors include other causes.
Condition: Ischemic Cardiomyopathy Interventions: Diagnostic Test: Stress Gated blood pool SPECT; Diagnostic Test: Dinamic SPECT Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences Enrolling by invitation
In conclusion, measurement of serum cTnI can be used to aid in diagnosing cardiac diseases in rhesus macaques. However, cTnI measurement does not replace echocardiographic evaluation to diagnose cardiac diseases in rhesus macaques due to the poor sensitivity of the assay and the weak correlation to with more established echocardiographic markers for cardiac disease. PMID: 32778203 [PubMed - as supplied by publisher]
In mid-March, a longstanding patient called my office, asking for hydroxychloroquine to ward off Covid-19. His call came on the heels of a press conference touting the miracle of this wonder drug. I had managed his stable ischemic cardiomyopathy for over a decade and in that time, he had called me only once, from Europe, when hospitalized with shortness of breath. A continent away, I could not titrate diuretic therapy or optimize afterload reduction. But I called him every day because he told me that my familiar voice on the phone was comfort enough.