Children's Commissioner publishes report Far less than they deserve on children with learning disabilities or autism living in mental health hospitals -

This reports describes the experience of children with a learning disability or autism who are placed in child/adolescent mental health hospitals. The report highlights too many children are being admitted to secure hospitals unnecessarily.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Publication date: Available online 19 July 2019Source: Molecular Aspects of MedicineAuthor(s): Ebrahim Hosseini, Zahra Bagheri-Hosseinabadi, Ilario De Toma, Moslem Jafarisani, Iman SadeghiAbstractIn the last decade, transcriptome analyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly, lncRNAs are abundantly enriched in the brain, displaying elaborate spatiotemporal expression profiles and modulation. They diversely participate in the delicate regulation of the central nervous system (CNS) development including se...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Conclusions and ImplicationsFindings suggest that potentially higher levels of perspective-taking ability among ASD-Sibs may contribute to better understanding of and therefore more positive affect toward their brother or sister with ASD. More research is needed to understand patterns of empathy among ASD-Sibs.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
ConclusionsPCIT-SM appears to be an effective treatment for children aged 4-10 with SM.
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
AbstractELMO domain containing 1 (ELMOD1) encodes a protein with GTPase-activating functions. Previous studies have confirmed its overexpression in brain tissues. Although no previous study has reported mutations in this gene in human subjects, spontaneous inactivating mutations in the mouse homolog of this gene have been associated with deafness and balance problems. In the current study, we have performed whole exome sequencing (WES) in a patient with intellectual disability. We found a novel mutation inELMOD1 gene (c.571delG, p.D191MfsTer25) in the proband and two other affected cases in the family. Segregation analysis...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
ánchez As the leading causes of human disability and mortality, neurological diseases affect millions of people worldwide and are on the rise. Although the general roles of several signaling pathways in the pathogenesis of neurodegenerative disorders have so far been identified, the exact pathophysiology of neuronal disorders and their effective treatments have not yet been precisely elucidated. This requires multi-target treatments, which should simultaneously attenuate neuronal inflammation, oxidative stress, and apoptosis. In this regard, astaxanthin (AST) has gained growing interest as a multi-target pharmac...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
This study investigated (a) how similar the heterogeneity in the cognitive and socioemotional developmental profiles was for children with ASD and ID, (b) the difference between the subjects’ profiles and those of typically developing children (TD) matched for developmental levels, (c) the skills existing with the lowest and highest developmental levels and (d) the relationship between developmental profiles in ASD and the severity of autism, ID and the overall developmental level. Participants. The sample was comprised of 119 children (101 boys and 18 girls) who ranged in chronological age (CA) from 21 months to 14 ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract A patient diagnosed with developmental delay, intellectual disability, and autistic and obsessive-compulsive symptoms was found to have a posterior fossa arachnoid cyst (PFAC) compressing the cerebellum. The patient was referred to our Ataxia Unit for consideration of surgical drainage of the cyst to improve his clinical constellation. This scenario led to an in-depth analysis including a literature review, functional resting-state MRI analysis of our patient compared to a group of controls, and genetic testing. While it is reasonable to consider that there may be a causal relationship between PFAC and ne...
Source: Cerebellum - Category: Neuroscience Authors: Tags: Cerebellum Source Type: research
ConclusionsThis is the first work describing a cohort of Brazilian individuals with PMS. Our results confirm the impact of 22q13 deletions on ASD and several comorbidities, such as hypotonia. The estimation of a minimal deletion size for developing lymphedema and renal problem can assist prediction of prognosis in PMS individuals, particularly those diagnosed in early infancy. We also identified one atypical individual carryingSHANK3 deletion, suggesting that resilience to such mutations occurs. This case expands the clinical spectrum of variability in PMS and opens perspectives to identify protective mechanisms that can m...
Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research
AbstractA patient diagnosed with developmental delay, intellectual disability, and autistic and obsessive-compulsive symptoms was found to have a posterior fossa arachnoid cyst (PFAC) compressing the cerebellum. The patient was referred to our Ataxia Unit for consideration of surgical drainage of the cyst to improve his clinical constellation. This scenario led to an in-depth analysis including a literature review, functional resting-state MRI analysis of our patient compared to a group of controls, and genetic testing. While it is reasonable to consider that there may be a causal relationship between PFAC and neurodevelop...
Source: The Cerebellum - Category: Neurology Source Type: research
ConclusionsThe DCE was sensitive to caregivers’ preferences for managing their child's coexisting cognitive/intellectual and emotional/behavior/developmental disability. Findings may help providers gauge treatment in a broader context of health outcomes.
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
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