C-Cbl negatively regulates TRAF6-mediated NF- κB activation by promoting K48-linked polyubiquitination of TRAF6.

Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-γ. PMID: 31123462 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research