Candida albicans dwelling in the mammalian gut.

Candida albicans dwelling in the mammalian gut. Curr Opin Microbiol. 2019 May 24;52:41-46 Authors: Pérez JC Abstract The yeast Candida albicans inhabits the gastrointestinal tract of most healthy adults, seemingly living there as a harmless commensal. The fungus on occasion disseminates from the gut to other internal organs causing life-threatening infections. Here, I review some of the most exciting advances in the study of gut colonization by C. albicans in the last few years. These developments highlight the close interplay between C. albicans and cohabiting microbes, the responses that commensal fungi elicit from the mammalian host, and the genetic determinants that allow the fungus to thrive in such a crowded and demanding ecosystem. PMID: 31132744 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research

Related Links:

CONCLUSIONS: Our results show that Candida parapsilosis complex isolates showed different levels of enzyme activity, biofilm production, and adhesion to epithelial cells.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
(CNN) — The US Food and Drug Administration is giving the maker of Purell products a stern warning: Stop making unproven claims that over-the-counter hand sanitizers help eliminate Ebola, MRSA or the flu. In a “warning letter” to Purell’s parent, Gojo Industries, the agency called out the company for making numerous marketing claims that potentially position its sanitizing products as a pharmaceutical drug rather than an over-the-counter topical antiseptic. The letter from the agency’s director of compliance cited numerous examples of what the FDA says are unproven claims for Purell products m...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston CNN Hand Sanitizer Source Type: news
In this study, four yeasts species (Wickerhamomyces anomalus, Candida glabrata, Candida utilis, and Candida parapsilosis) were evaluated with two different chemically defined media and tequila vinasses. Differences in the aroma compounds production were observed depending on the medium and yeast species used. In tequila vinasses, the highest concentration (65 mg/L) of 2-PEA was reached by C. glabrata, the inhibitory compounds decreased biomass production and synthesis of 2-PEA, and biochemical and chemical oxygen demands were reduced by more than 50%. Tequila vinasses were suitable for the production of 2-phenylethy...
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
ConclusionsThe evaluated studies presented a high risk of bias and weak evidence of the effects of chemical agents to reduce CFU counts of Candida spp. Only chlorhexidine and chlorine dioxide demonstrated some evidence of a reduction in Candida spp. colonization. Clinical trials with better methodological designs should be performed to clarify the effectiveness of these solutions in prosthesis decontamination.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Rezafungin (RZF) is a novel echinocandin in development for prevention of invasive fungal disease caused by Candida, Aspergillus, and Pneumocystis species in patients undergoing blood and marrow transplantation. RZF has a favorable safety and tolerability profile, a low risk of drug-drug interactions and with its stability, pharmacokinetics that allow for once-weekly dosing with broad distribution to the lung and other fungal target organs.We previously demonstrated RZF efficacy in preventing Pneumocystis infection in an immunosuppressed mouse model.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 502 Source Type: research
AbstractIn a search for novel therapeutic agents against pathogenic fungal species,Candida in addition to bacterial species, novel spinel nanoferrites were assayed against four pathogenic fungi isolated from different clinical samples of ear and skin infections:Aspergillus flavus, A. niger, A. terrus and A. fumigatus, fourCandia species:Candida albicans, C. parapsilosis, C. krusei andC. tropicales, and four bacterial species: two Gram +ve:Bacillus subtilis andStreptococcus pyogenes, and two Gram −ve:Pseudomonas vulgaris andEscherichia coli. It was found that the assayed compounds displayed different levels of antifun...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
This study explore the in silico and in vitro comparative analysis of cofactor NADP binding mechanism in rossmann fold of isolated M. caribbica and other xylose fermenting Debaryomycetaceae family yeast. The rossmaan fold analysis of M. caribbica and Debaryomycetaceae family of yeast revealed, xylose fermenting organisms Scheffersomyces stipitis, Debaryomyces hansenii, Debaryomyces nepalensis, Candida parapsilosis, Candida maltose has divergence structure of rosmann fold. Whereas M. caribbica and Calamus tenuis has unique structure of rossmann fold. Also, the identified rossmann fold of Debaryomycetaceae family yeast and i...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
"Clinical Aspects of Chronic Granulomatous Disease in Upper Egypt". Immunol Invest. 2020 Jan 22;:1-13 Authors: El-Mokhtar MA, Salama EH, Fahmy EM, Mohamed ME Abstract Chronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency disorder that affects phagocytes and is characterized by a marked increased susceptibility to severe bacterial and fungal infections. We aimed to describe the clinical presentations of pediatric patients with CGD in Upper Egypt and to identify the defective component of NADPH oxidase. Pediatric patients diagnosed with CGD within one year from Januar...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Publication date: February 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 2Author(s): Ricardo Miguel Costa de Freitas, José Guilherme Mendes Pereira Caldas, Silvia Mazzali Verst, Ana Oliveira Hoff, João Evangelista Bezerra Neto, Maria Candida Barisson Villares Fragoso
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsA disproportionately high burden ofC.trachomatis is present among young asymptomatic women in Fiji of iTaukei ethnicity despite the low number of lifetime partners. Syndromic management and lack of barrier contraceptives contribute to hyperendemic levels. Strategic STI education and screening of at-risk adolescents, young women, and their partner(s) with appropriate treatment are urgently needed to control the epidemic.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
More News: Candida | Gastroenterology | Genetics | Microbiology | Study